Vitamin K is a fat-soluble vitamin that plays an essential role in the body's blood clotting process and has drawn growing research interest for its contributions to bone and dental health. It exists in several forms, with Vitamin K1 (phylloquinone) found primarily in leafy green vegetables and Vitamin K2 (as menaquinone-4 and menaquinone-7) found in fermented foods and certain animal products. Studies indicate that K2 in particular may support calcium metabolism by helping direct calcium toward bones and teeth rather than soft tissues, which has made it a focus of research into long-term skeletal health. Research also suggests that adequate vitamin K intake is associated with normal metabolic function, though individual needs can vary and the science continues to evolve.
Compare this supplementResearch suggests that vitamin K plays a well-established and foundational role in blood clotting, with multiple revi...
View studies →Research suggests that vitamin K plays a meaningful role in bone health, primarily through its ability to activate ke...
View studies →The studies provided do not contain any research on Vitamin K or dental and oral health — the linked sources address ...
View studies →Research suggests that the direct evidence linking Vitamin K supplementation to broad metabolic support is limited wi...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 45–180 mcg | Daily | bone health and cardiovascular support (Vitamin K2/MK-7 form) | Common in RCTs using menaquinone-7 for osteocalcin activation and arterial calcification |
| Capsule | 1,000–45,000 mcg | Daily | bone health in osteoporosis patients (Vitamin K2/MK-4 form, pharmacological dose) | Used in Japanese clinical trials with menatetrenone (MK-4) for osteoporosis treatment |
| Capsule | 200–360 mcg | Daily | dental and oral health, carboxylation support | Studied in trials assessing gingival health and osteocalcin carboxylation markers |
| Capsule | 50–100 mcg | Daily | metabolism support and insulin sensitivity (Vitamin K2/MK-7) | Used in RCTs examining osteocalcin-mediated glucose metabolism and insulin regulation |
| Tablet | 100–300 mcg | Daily | bone health and osteoporosis prevention (Vitamin K1/phylloquinone) | Common in clinical trials examining bone mineral density and fracture risk |
| Tablet | 90–120 mcg | Daily | general health and blood clotting support (adequate intake reference level) | Based on dietary reference intakes; used as reference dose in observational and supplementation studies |