Melatonin is a naturally occurring compound produced by the pineal gland that plays a central role in regulating the body's circadian rhythm and sleep-wake cycle. Research suggests that supplemental melatonin may support sleep quality, particularly for individuals experiencing occasional sleeplessness, jet lag, or disrupted sleep patterns, and studies indicate it has also drawn scientific interest for its antioxidant properties, potential benefits for eye health, and roles in managing acid reflux and tinnitus symptoms. Available in immediate release, extended release, sublingual, and liquid forms, melatonin is one of the most widely studied sleep-related compounds, with a generally favorable safety profile noted across numerous clinical trials. As with any supplement, individual responses can vary, and the existing research continues to evolve as scientists explore its broader applications.
Compare this supplementResearch suggests that melatonin may help reduce symptoms of gastroesophageal reflux disease such as heartburn and ep...
View studies →Research suggests that melatonin supplementation is associated with meaningful improvements in certain aspects of sle...
View studies →Research suggests that melatonin may offer modest benefits for tinnitus patients, particularly in improving sleep qua...
View studies →Research suggests a meaningful biological connection between melatonin and eye health, particularly through the retin...
View studies →Research suggests that melatonin may offer meaningful antioxidant and skin-protective properties, with a 2018 review ...
View studies →Both promote sleep and relaxation; the combined sedative effect may be strong.
View details →St. John's Wort may reduce melatonin effectiveness by increasing its metabolism.
View details →Both promote relaxation and sleep through complementary, gentle mechanisms.
View details →Both support sleep quality through complementary mechanisms and are commonly combined.
View details →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Tablet | 3–10 mg | Daily | Acid reflux and heartburn (GERD symptom relief) | Used in clinical trials examining melatonin's role in lower esophageal sphincter function |
| Tablet | 1–10 mg | Daily | Antioxidant support and oxidative stress reduction | Range used across clinical studies examining melatonin's antioxidant and anti-inflammatory properties |
| Tablet | 3–5 mg | Daily | Eye health and intraocular pressure support | Used in clinical research examining melatonin's role in glaucoma and retinal oxidative stress |
| Tablet | 2–3 mg | Daily | Jet lag and circadian rhythm disruption | Based on RCTs studying circadian phase shifting and jet lag protocols |
| Tablet | 0.5–5 mg | Daily | Sleep quality and sleep onset latency | Common in clinical trials for insomnia and sleep disturbances; lower doses often as effective as higher |
| Tablet | 3–5 mg | Daily | Tinnitus symptom management | Based on RCTs investigating melatonin for tinnitus; administered at bedtime |