Glutathione is a tripeptide composed of three amino acids — cysteine, glycine, and glutamic acid — and serves as one of the body's most abundant and critical endogenous antioxidants. Research suggests it plays a central role in neutralizing free radicals, supporting detoxification pathways in the liver, and maintaining healthy immune function. Studies indicate that glutathione levels naturally decline with age and may be further depleted by stress, poor nutrition, and environmental toxin exposure, which has driven interest in supplemental forms such as liposomal, S-acetyl, and reduced glutathione designed to improve absorption. Emerging research has also explored its potential benefits for skin health, including effects on melanin production and overall complexion, as well as its supportive role in respiratory health and cellular resilience, though more large-scale human trials are needed to fully establish optimal applications.
Compare this supplementResearch suggests that glutathione plays a meaningful role in skin health, primarily through its function as a key an...
View studies →Research suggests that glutathione plays a central role in protecting cells from oxidative stress, and that declining...
View studies →Research suggests that glutathione plays a central and well-documented role in cellular detoxification, functioning b...
View studies →Research suggests that glutathione plays a meaningful role in immune function, with several studies indicating that r...
View studies →Research suggests that glutathione plays a meaningful role in liver health, particularly through its function as a ke...
View studies →Research suggests that glutathione plays a central role in the body's antioxidant defense systems, with studies consi...
View studies →Research suggests that glutathione and its related enzymatic pathways play a meaningful role in protecting respirator...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 250–500 mg | Daily | Antioxidant support, general health, immune function | Common in clinical trials on oral GSH supplementation |
| Capsule | 500–1,000 mg | Daily | Skin lightening, skin health, anti-aging | Based on RCTs examining melanin reduction and skin tone outcomes |
| Liquid | 20–40 mg | Daily | Antioxidant support, detoxification, bioavailability-enhanced delivery | Used in liposomal glutathione clinical studies |
| Liquid | 600–1,200 mg | As needed | Respiratory health, cystic fibrosis, lung oxidative stress | Based on inhaled glutathione trials in respiratory conditions |
| Tablet | 500 mg | Twice daily | Liver health, non-alcoholic fatty liver disease support | Dose used in RCTs examining liver enzyme outcomes |