Both support sleep quality through complementary mechanisms and are commonly combined.
Magnesium supports GABA receptors and muscle relaxation. Melatonin regulates circadian rhythm.
A popular and generally safe sleep combination. Take both 30-60 minutes before bed.
Known drug category interactions for these supplements. Especially relevant if you take prescription medications.
Magnesium binds to these antibiotics in the gut, significantly reducing their absorption and effectiveness.
Take magnesium at least 2 hours before or 4-6 hours after these antibiotics.
Melatonin may affect blood pressure and interact with some antihypertensive drugs.
Monitor blood pressure if combining. Some people experience higher blood pressure with melatonin — effects vary.
Reference values for safe daily intake of these supplements.
UL is for supplemental magnesium only (not dietary). Diarrhea is the primary adverse effect.