Iron & Magnesium

Caution Absorption Caution Timing
Caution Absorption

High-dose magnesium supplements may reduce iron absorption when taken together.

Mechanism

Magnesium and iron can compete for absorption in the gastrointestinal tract at higher supplemental doses.

Recommendation

Separate magnesium and iron supplements by 2 hours for best absorption of both.

Sources

  • NIH ODS
Caution Timing

Take magnesium and iron supplements at different times of day for best absorption.

Mechanism

Both minerals compete for absorption. Iron is best absorbed on an empty stomach in the morning; magnesium is often better tolerated in the evening.

Recommendation

Take iron in the morning with vitamin C. Take magnesium in the evening or at a different meal.

Sources

  • NIH ODS

Drug interaction context

Known drug category interactions for these supplements. Especially relevant if you take prescription medications.

Warning Magnesium × Antibiotics (tetracyclines, fluoroquinolones)

Magnesium binds to these antibiotics in the gut, significantly reducing their absorption and effectiveness.

Take magnesium at least 2 hours before or 4-6 hours after these antibiotics.

Warning Iron × Thyroid medication (levothyroxine)

Iron reduces levothyroxine absorption.

Take levothyroxine at least 4 hours before or after iron supplements.

Check your full stack including medications →

Tolerable upper intake limits

Reference values for safe daily intake of these supplements.

Magnesium
350.000 mg
adults NIH ODS / IOM

UL is for supplemental magnesium only (not dietary). Diarrhea is the primary adverse effect.

Iron
45.000 mg
adults NIH ODS / IOM

GI distress above UL. Risk of iron overload in people with hemochromatosis.

Medical Disclaimer: Noyemi provides information from published research for educational purposes only. This content is not medical advice and does not replace consultation with a qualified healthcare provider. Always consult your doctor before starting, stopping, or changing any supplement regimen, especially if you take medications or have existing health conditions.