Vitex agnus-castus, commonly known as chasteberry, is a fruit extract with a long history of traditional use for supporting women's hormonal health. Research suggests that vitex may influence the pituitary gland and help modulate levels of prolactin and other hormones involved in the menstrual cycle, which is why it has been widely studied in the context of PMS relief, cycle regularity, and fertility support. Several clinical trials indicate that vitex supplementation may reduce common premenstrual symptoms such as breast tenderness, mood changes, and bloating, with some studies also exploring its potential role during the menopausal transition. While the body of evidence is promising, results can vary, and the mechanisms behind its hormonal activity continue to be an active area of scientific investigation.
Compare this supplementResearch suggests that Vitex agnus-castus (chasteberry) has meaningful evidence supporting its use for cyclic mastalg...
View studies →Research suggests that Vitex agnus-castus (chasteberry) shows more consistent evidence for PMS and premenstrual sympt...
View studies →Research suggests that Vitex agnus-castus shows the most consistent promise for reducing premenstrual syndrome sympto...
View studies →Research suggests that Vitex agnus-castus (chasteberry) shows promise for reducing PMS symptoms, with the most direct...
View studies →Research suggests that Vitex agnus-castus may offer some support for fertility-related outcomes, though the evidence ...
View studies →Research suggests that Vitex agnus-castus and related Vitex species may influence reproductive hormonal pathways, wit...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 400–500 mg | Daily | PMS relief and menstrual cycle regulation | Common standardized dried fruit/berry extract dose in clinical trials |
| Extract | 4 mg | Daily | Hormonal balance and fertility support | Used in RCTs with Mastodynon formulation; common in European clinical research |
| Extract | 160–240 mg | Daily | Menopause support and hot flash reduction | Used in menopause-focused RCTs; based on BNO 1095 extract studies |
| Extract | 20–40 mg | Daily | PMS relief and menstrual health | Common in clinical trials using standardized Ze 440 extract (e.g., Schellenberg 2001, BMJ) |
| Liquid | 40 mg | Daily | Breast pain (mastalgia) and breast health | Consistent dose used across multiple RCTs for cyclic mastalgia treatment |