Research suggests that manganese plays a role in metabolic processes at the cellular and molecular level, with studies pointing to its involvement in enzyme function, energy storage metabolism, and micronutrient interactions relevant to immune and systemic health. A 2025 laboratory study identified a previously unknown manganese-dependent enzyme activity involved in polyphosphate metabolism in yeast, while a separate ocean biogeochemistry study demonstrated that microbes actively substitute manganese into metabolic proteins under nutrient-limited conditions, underscoring its functional versatility as a cofactor. A large 2021 computational analysis of over 6,600 papers found that manganese deficiency, alongside other micronutrients, was associated with disrupted immune cell balance, though this study was observational and text-based rather than a controlled trial. The available evidence bearing on manganese and metabolism in this collection is largely indirect, drawn from microbial, ecological, and genetic research rather than human clinical trials, so conclusions about its relevance to human metabolic health should be interpreted with caution.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| Temporal genome dynamics of ST39 <i>Klebsiella pneumoniae</i> in a neonatal... | Other | 2025 | Neutral | 90 |
| Elemental allocation to molecular drivers of biogeochemistry in the Southern ... | Other | 2025 | Supports | 85 |
| Common factor GWAS identifies shared risk loci between chronic widespread pai... | Other | 2025 | Neutral | 85 |
| The gonococcal vaccine candidate antigen NGO1701 is a <i>N. gonorrhoeae</i> p... | Other | 2025 | Neutral | 80 |
| Genome-wide association study of blood mercury in European pregnant women and... | Other | 2023 | Neutral | 80 |
| Metagenomic Insights Into Microbial Controls of Carbon Cycling in Alpine Soils | Other | 2025 | Neutral | 75 |
| Local patterns of genetic sharing challenge the boundaries between neuropsych... | Other | 2024 | Neutral | 75 |
| A Screening Approach Unveils an Unknown Mn<sup>2+</sup>-dependent Endopolypho... | Other | 2025 | Supports | 70 |
| Computational systematics of nutritional support of vaccination against viral... | Other | 2021 | Supports | 70 |
| Shared genetic basis for brain structure, insulin resistance and inflammation... | Other | 2025 | Neutral | 65 |
| Genome-wide association study reveals loci with sex-specific effects on plasm... | Other | 2022 | Neutral | 65 |
| Aridity drives global convergence of desert microbiomes and biogeochemical ac... | Other | 2025 | Neutral | 60 |
| Follow-up study on serum cholesterol profiles in recovered COVID-19 patients | Other | 2020 | Neutral | 60 |
| A <i>Mycobacterium tuberculosis</i> Mbox controls a conserved, small upstream... | Other | 2025 | Neutral | 55 |
| Current Understanding of COVID-19 Clinical Course and Investigational Treatments | Other | 2020 | Neutral | 55 |
| Recovery of microbial ecophysiology and carbon accrual functions in peatlands... | Other | 2025 | Neutral | 50 |
| Renal Coenzyme A (CoA) Production Fuels Stem Cell Proliferation and Tumor Growth | Other | 2025 | Neutral | 45 |
| Mini-bacterioferritins: Structural insight into a new type of ferritin-like p... | Other | 2025 | Neutral | 40 |
| A chromosome-level assembly and functional genomic resources for the model an... | Other | 2025 | Neutral | 35 |
| PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor | Other | 2024 | Neutral | 30 |
| A novel quinone biosynthetic pathway illuminates the evolution of aerobic met... | Other | 2024 | Neutral | 25 |
| Impact of Vitamin D on Gene Expression in Atlantic Salmon Skin and Potential ... | Other | 2025 | Neutral | 20 |
| Drivers of methane-cycling archaeal abundances, community structure, and cata... | Other | 2024 | Neutral | 15 |