Lactobacillus fermentum is a lactic acid-producing bacterium naturally found in fermented foods and the human gastrointestinal and urogenital tracts, commonly available in probiotic capsule form. Research suggests it may play a supportive role in cholesterol management, with some studies indicating it can help reduce total and LDL cholesterol levels through its ability to assimilate cholesterol and influence bile salt metabolism. Studies also point to potential immune-modulating properties, including enhanced activity of natural killer cells and reduced duration of respiratory infections in certain populations. Additionally, preliminary research indicates that Lactobacillus fermentum may contribute to maintaining a healthy vaginal microbiome by producing hydrogen peroxide and competing with harmful microorganisms, though more large-scale human trials are needed to fully understand the breadth of its benefits.
Compare this supplementResearch suggests that Lactobacillus fermentum may support immune function through several mechanisms, including prom...
View studies →Research suggests that certain probiotic consortia containing Lactobacillus fermentum may support antiviral immune re...
View studies →Research suggests that Lactobacillus fermentum is a naturally occurring constituent of the vaginal microbiome in some...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 99,999,999.99 CFU | Daily | cholesterol management | Based on RCTs using L. fermentum NCIMB 5221 and similar strains for lipid profile improvement |
| Capsule | 99,999,999.99 CFU | Twice daily | immune function and respiratory health | Common in clinical trials examining immune response and upper respiratory tract infection prevention |
| Capsule | 57,000,000 CFU | Daily | vaginal health and bacterial vaginosis | Based on clinical trials using L. fermentum LF10 in combination products for vaginal microbiome restoration |
| Powder | 99,999,999.99 CFU | Daily | general immune support | Range observed across multiple RCTs studying L. fermentum supplementation in healthy adults |
| Tablet | 99,999,999.99 CFU | Daily | cholesterol management | Dose used in RCTs with probiotic cheese and fermented dairy delivery formats for cardiovascular risk factors |