Brahmi (Centella Asiatica / Gotu Kola) for Skin Health

Moderate evidence 16 studies

Research suggests that Centella asiatica (Gotu Kola) has meaningful evidence supporting its role in skin health, particularly through its active triterpene compounds — asiaticoside, madecassoside, asiatic acid, and madecassic acid — which studies consistently indicate promote collagen synthesis, fibroblast proliferation, and wound healing across a range of conditions including burns, scars, stretch marks, and diabetic ulcers. The available evidence base consists primarily of reviews and systematic reviews, with a smaller number of clinical trials examining topical formulations, and the overall direction of findings is supportive, with studies also noting benefits for skin hydration, barrier function, photoprotection, and anti-inflammatory effects relevant to conditions like psoriasis and hypertrophic scars. Studies indicate that newer delivery technologies such as hydrogels and nanostructures may enhance the plant's effectiveness when applied topically, and at least one clinical trial supports its use in reducing scar outcomes while another demonstrates improvements in stretch marks through combination therapy. It is worth noting that the research landscape relies heavily on review-level evidence and in vitro or small clinical studies rather than large-scale randomized controlled trials, so while the general picture is consistently positive, higher-quality independent trials would strengthen the conclusions that can be drawn.

Related studies

Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.

Title Type Year Direction Match
Centella asiatica in cosmetology. Review 2013 Supports 95
Topical Application of Centella asiatica in Wound Healing: Recent Insights in... Review 2024 Supports 92
Therapeutic properties and pharmacological activities of asiaticoside and mad... Review 2023 Supports 92
Centella asiatica and Its Metabolite Asiatic Acid: Wound Healing Effects and ... Review 2023 Supports 90
Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and P... Review 2021 Supports 88
Centella asiatica in dermatology: an overview. Review 2014 Supports 88
A Systematic Review of the Effect of Centella asiatica on Wound Healing. Systematic review 2022 Supports 87
Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review. Review 2020 Supports 82
Effectiveness of Fractional CO2 Laser and Topical Centella asiatica Combinati... Other 2024 Supports 80
Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Contain... Other 2016 Supports 80
The effect of Centella Asiatica cream on scar development in patients who und... Other 2023 Supports 78
Ethnobotany, Phytochemistry and Pharmacological Features of Centella asiatica... Review 2021 Supports 75
Centella asiatica protects against UVB-induced HaCaT keratinocyte damage thro... Other 2012 Supports 75
Madecassoside-functionalized platinum-based liposomes for sensitive skin: Enh... Other 2026 Supports 72
Cosmeceuticals in photoaging: A review. Systematic review 2024 Supports 72
Nutritional support for wound healing. Review 2003 Supports 70

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Medical Disclaimer: Noyemi provides information from published research for educational purposes only. This content is not medical advice and does not replace consultation with a qualified healthcare provider. Always consult your doctor before starting, stopping, or changing any supplement regimen, especially if you take medications or have existing health conditions.