Research suggests that Centella asiatica, particularly its standardized triterpenic fraction (TTFCA), has a relatively consistent body of evidence supporting its role in improving circulation-related outcomes, especially in conditions involving chronic venous insufficiency, venous hypertension, and diabetic microangiopathy. Studies indicate benefits across multiple measurable markers, including reductions in capillary fluid leakage, improvements in skin blood flow and oxygen levels, decreased ankle swelling, and faster healing of venous ulcers, with this evidence coming from a range of sources including multiple randomized controlled trials, several Cochrane meta-analyses, and a 2025 pilot study — nearly all pointing in a supportive direction. The proposed mechanisms, reviewed in both older and more recent literature, center on the plant's apparent ability to modulate collagen production and structural proteins in vein walls, as well as its anti-inflammatory and vascular-stabilizing properties. That said, individual trials are often small in scale, some studies rely on surrogate measures rather than hard clinical endpoints, and reviewers across multiple papers consistently call for larger and longer trials before stronger conclusions can be drawn.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| Improvement in venous ulcer closure and healing with Centellicum®. | Other | 2025 | Supports | 98 |
| Effects of the total triterpenic fraction of Centella asiatica in venous hype... | RCT | 2001 | Supports | 97 |
| Total triterpenic fraction of Centella asiatica in chronic venous insufficien... | Review | 2001 | Supports | 97 |
| Capillary filtration and ankle edema in patients with venous hypertension tre... | RCT | 1990 | Supports | 97 |
| Improvement of capillary permeability in patients with venous hypertension af... | Other | 1990 | Supports | 97 |
| Herbal drugs in chronic venous disease treatment: An update. | Review | 2024 | Supports | 95 |
| Treatment of diabetic microangiopathy and edema with total triterpenic fracti... | RCT | 2001 | Supports | 95 |
| Evaluation of treatment of diabetic microangiopathy with total triterpenic fr... | RCT | 2001 | Supports | 95 |
| A review of the microcirculation in skin in patients with chronic venous insu... | Review | 2006 | Supports | 93 |
| Chemical, pharmacological and clinical profile of the East Asian medical plan... | Review | 2000 | Supports | 93 |
| Phlebotonics for venous insufficiency. | Meta-analysis | 2020 | Supports | 92 |
| Phlebotonics for venous insufficiency. | Meta-analysis | 2016 | Supports | 92 |
| Phlebotonics for venous insufficiency. | Meta-analysis | 2005 | Supports | 92 |
| Anti-Inflammatory and Anti-Vascular Leakage Effects by Combination of Centell... | Other | 2021 | Supports | 88 |
| Ethnobotany, Phytochemistry and Pharmacological Features of Centella asiatica... | Review | 2021 | Supports | 88 |
| Therapeutic potential of natural compounds in inflammation and chronic venous... | Review | 2019 | Supports | 88 |
| The Role of Food Supplementation in Microcirculation-A Comprehensive Review. | Review | 2021 | Supports | 75 |
| Hemorrhoids and varicose veins: a review of treatment options. | Review | 2001 | Supports | 72 |
| A new cyclodextrin-grafted viscose loaded with aescin formulations for a cosm... | Other | 2011 | Supports | 62 |