Brahmi (Centella Asiatica / Gotu Kola) for Blood Circulation

Strong evidence 19 studies

Research suggests that Centella asiatica, particularly its standardized triterpenic fraction (TTFCA), has a relatively consistent body of evidence supporting its role in improving circulation-related outcomes, especially in conditions involving chronic venous insufficiency, venous hypertension, and diabetic microangiopathy. Studies indicate benefits across multiple measurable markers, including reductions in capillary fluid leakage, improvements in skin blood flow and oxygen levels, decreased ankle swelling, and faster healing of venous ulcers, with this evidence coming from a range of sources including multiple randomized controlled trials, several Cochrane meta-analyses, and a 2025 pilot study — nearly all pointing in a supportive direction. The proposed mechanisms, reviewed in both older and more recent literature, center on the plant's apparent ability to modulate collagen production and structural proteins in vein walls, as well as its anti-inflammatory and vascular-stabilizing properties. That said, individual trials are often small in scale, some studies rely on surrogate measures rather than hard clinical endpoints, and reviewers across multiple papers consistently call for larger and longer trials before stronger conclusions can be drawn.

Related studies

Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.

Title Type Year Direction Match
Improvement in venous ulcer closure and healing with Centellicum®. Other 2025 Supports 98
Effects of the total triterpenic fraction of Centella asiatica in venous hype... RCT 2001 Supports 97
Total triterpenic fraction of Centella asiatica in chronic venous insufficien... Review 2001 Supports 97
Capillary filtration and ankle edema in patients with venous hypertension tre... RCT 1990 Supports 97
Improvement of capillary permeability in patients with venous hypertension af... Other 1990 Supports 97
Herbal drugs in chronic venous disease treatment: An update. Review 2024 Supports 95
Treatment of diabetic microangiopathy and edema with total triterpenic fracti... RCT 2001 Supports 95
Evaluation of treatment of diabetic microangiopathy with total triterpenic fr... RCT 2001 Supports 95
A review of the microcirculation in skin in patients with chronic venous insu... Review 2006 Supports 93
Chemical, pharmacological and clinical profile of the East Asian medical plan... Review 2000 Supports 93
Phlebotonics for venous insufficiency. Meta-analysis 2020 Supports 92
Phlebotonics for venous insufficiency. Meta-analysis 2016 Supports 92
Phlebotonics for venous insufficiency. Meta-analysis 2005 Supports 92
Anti-Inflammatory and Anti-Vascular Leakage Effects by Combination of Centell... Other 2021 Supports 88
Ethnobotany, Phytochemistry and Pharmacological Features of Centella asiatica... Review 2021 Supports 88
Therapeutic potential of natural compounds in inflammation and chronic venous... Review 2019 Supports 88
The Role of Food Supplementation in Microcirculation-A Comprehensive Review. Review 2021 Supports 75
Hemorrhoids and varicose veins: a review of treatment options. Review 2001 Supports 72
A new cyclodextrin-grafted viscose loaded with aescin formulations for a cosm... Other 2011 Supports 62

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Medical Disclaimer: Noyemi provides information from published research for educational purposes only. This content is not medical advice and does not replace consultation with a qualified healthcare provider. Always consult your doctor before starting, stopping, or changing any supplement regimen, especially if you take medications or have existing health conditions.