Gotu Kola for Blood Circulation

Strong evidence 12 studies

Research suggests that Gotu Kola — particularly its standardized triterpenic fractions and key active compounds like asiaticoside and asiatic acid — may support blood circulation by reducing abnormal fluid leakage from capillaries, improving microvascular blood flow, and aiding the structural integrity of vein walls. The evidence base includes several randomized controlled trials and clinical studies that broadly support benefits in conditions such as chronic venous insufficiency, venous hypertension, and diabetic microangiopathy, with one pilot study also reporting improved healing of venous ulcers alongside measurable gains in skin microcirculation. Supporting reviews highlight multiple potential mechanisms — including anti-inflammatory, antioxidant, and collagen-regulating effects — that may work together to influence vascular health, and the compound has generally been reported as well tolerated across studies. However, limitations worth noting include relatively small sample sizes in available trials, some studies conducted in animal models, variability in the specific extracts and formulations tested, and the need for larger and longer-duration clinical investigations before firm conclusions can be drawn.

Related studies

Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.

Title Type Year Direction Match
Preparation and evaluation of PEGylated asiatic acid nanostructured lipid car... Other 2020 Neutral 72
A review of the microcirculation in skin in patients with chronic venous insu... Review 2006 Supports 67
Increase water solubility of Centella asiatica extract by indigenous bioenhan... Other 2022 Neutral 62
TECA (Titrated Extract of Centella Asiatica): new microcirculatory, biomolecu... Review 2011 Supports 57
Total triterpenic fraction of Centella asiatica in chronic venous insufficien... Review 2001 Supports 52
Improvement in venous ulcer closure and healing with Centellicum®. Other 2025 Supports 47
In vivo disposition and metabolism of madecassoside, a major bioactive consti... Other 2013 Neutral 42
Effects of Asiaticoside Treatment on the Survival of Random Skin Flaps in Rats. Other 2021 Supports 37
Improvement of capillary permeability in patients with venous hypertension af... Other 1990 Supports 32
Effects of the total triterpenic fraction of Centella asiatica in venous hype... RCT 2001 Supports 27
Comparative study of the efficacy and tolerability of a unique topical scar p... RCT 2013 Neutral 22
Evaluation of treatment of diabetic microangiopathy with total triterpenic fr... RCT 2001 Supports 17

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Medical Disclaimer: Noyemi provides information from published research for educational purposes only. This content is not medical advice and does not replace consultation with a qualified healthcare provider. Always consult your doctor before starting, stopping, or changing any supplement regimen, especially if you take medications or have existing health conditions.