Chrysanthemum for Blood Pressure Regulation

Research suggests that chrysanthemum, particularly Chrysanthemum indicum and Chrysanthemum morifolium, may support blood pressure regulation through multiple biological mechanisms, including modulation of inflammatory pathways, improvement of gut microbiota and intestinal barrier integrity, and influence on vascular signaling systems such as the renin-angiotensin pathway. Studies indicate that flavonoid compounds appear to be the primary active constituents, with one rat study finding that a buddleoside-rich extract reduced blood pressure in metabolic hypertension by dampening gut-derived inflammatory signals, and another finding that chrysanthemum extract reduced cardiac structural changes associated with high blood pressure. The available evidence comes primarily from animal studies, computational network pharmacology modeling, and laboratory experiments rather than human clinical trials, which represents a significant limitation in drawing conclusions about efficacy in people. Two studies also examined chrysanthemum in contexts not directly related to blood pressure, such as metabolic and uric acid regulation, which while tangentially relevant does not add direct evidence for antihypertensive effects, and no randomized controlled trials or robust human studies were included in this body of research.