Research suggests that yerba mate, particularly in combination with caffeine-containing formulations, may support energy levels and reduce feelings of fatigue, with available evidence pointing in a generally supportive direction. A double-blind crossover study found that a multi-ingredient thermogenic supplement containing yerba mate and caffeine significantly increased resting energy expenditure and improved self-reported alertness and energy while reducing perceived fatigue, with effects most pronounced in the first one to two hours after ingestion. A broader review of caffeine as a dietary ingredient further supports the notion that caffeine-containing botanicals like yerba mate are associated with reduced fatigue and enhanced mental alertness, and are considered generally safe at moderate intake levels by major regulatory bodies. However, notable limitations apply: the crossover study used a small sample of only 12 habitual caffeine consumers and tested a multi-ingredient product rather than yerba mate in isolation, making it difficult to attribute effects to yerba mate specifically, and the review focused broadly on caffeine rather than yerba mate as a standalone ingredient.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| Caffeine (1, 3, 7-trimethylxanthine) in foods: a comprehensive review on cons... | Review | 2010 | Supports | 72 |
| Effects of ingestion of a commercially available thermogenic dietary suppleme... | Other | 2013 | Supports | 67 |