White willow bark, derived from the Salix alba tree, has a long history of traditional use dating back thousands of years and is often regarded as nature's predecessor to modern aspirin. Its key active compound, salicin, is converted in the body to salicylic acid, which is believed to be largely responsible for its effects. Research suggests that white willow bark extract may help support the body's natural response to inflammation and discomfort, with studies indicating potential benefits for headaches, lower back pain, and joint stiffness associated with conditions like osteoarthritis. Some clinical research has also explored its role in fever management and migraine relief, though findings vary in strength and scope. As with many herbal supplements, the existing evidence is promising but continues to evolve as more rigorous trials are conducted.
Compare this supplementResearch suggests that white willow bark extract has anti-inflammatory properties supported by a modest body of evide...
View studies →Research suggests that white willow bark extract may offer meaningful pain relief in humans, with a randomized contro...
View studies →Research suggests that white willow bark, as a source of salicylate compounds, raises particular safety concerns in t...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 400–800 mg | Three times daily | General pain relief and fever management (crude bark preparations) | Traditional and herbal medicine use; equivalent to standardized salicin content |
| Extract | 240 mg | Daily | Headache and migraine relief | Based on extrapolation from pain-related RCTs; standardized to 15% salicin |
| Extract | 240 mg | Daily | Joint pain relief and osteoarthritis | Dose used in RCTs showing significant pain reduction vs placebo |
| Extract | 120 mg | Daily | Low back pain management | Lower dose studied in Chrubasik et al. RCTs; some efficacy noted |
| Extract | 120–240 mg | Daily | Pain relief and anti-inflammatory (standardized to salicin content) | Common in clinical trials for low back pain and osteoarthritis |