Vitamin D for Respiratory Health

Moderate evidence 45 studies

Research suggests that vitamin D plays a meaningful role in respiratory health, with a 2009 review highlighting associations between higher vitamin D levels and better lung function, and proposing that the vitamin may help suppress harmful lung inflammation while strengthening immune defenses against respiratory infections. A 2014 review found that lower vitamin D levels are linked to greater asthma severity, reduced responsiveness to steroid medications, and markers of airway inflammation, and explored how the vitamin may shift immune activity toward a less inflammatory state. However, the evidence is not uniformly positive — a 2024 review of children's respiratory diseases noted that while observational studies consistently find associations between vitamin D deficiency and respiratory illness, clinical trials testing supplementation have produced less encouraging results, and a 2023 systematic review examining mental health outcomes in adults with respiratory conditions found only limited and inconsistent benefit across five available randomized controlled trials. Taken together, the body of evidence — spanning reviews, observational research, and a small number of trials — suggests a plausible and biologically grounded relationship between vitamin D status and respiratory health, but current research does not yet firmly establish that supplementation produces consistent clinical benefit, and further well-designed trials are needed to clarify its role.

Related studies

Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.

Title Type Year Direction Match
Vitamin D and Brain Health. Review 2026 Neutral 100
Vitamin D deficiency can impair respiratory health. Other 2018 Supports 95
Prescription Cascades Associated with Acetylcholinesterase Inhibitors Use: A ... Other 2025 Neutral 90
Vitamin D and respiratory health. Review 2009 Supports 90
The effect of vitamin D and calcium supplementation on gut microbiota composi... Other 2025 Neutral 85
A micro-costing of latent tuberculosis infection testing and treatment in adu... Other 2025 Neutral 85
Supplementation of Vitamin D and Mental Health in Adults with Respiratory Sys... Systematic review 2023 Mixed 85
Impact of Vitamin D on Gene Expression in Atlantic Salmon Skin and Potential ... Other 2025 Neutral 80
Identifying profiles, trajectories, burden, social and biological factors in ... Other 2025 Neutral 80
Immunoregulatory mechanisms of vitamin D relevant to respiratory health and a... Review 2014 Supports 80
A <i>Slc5a6</i> Deficient Mouse Model Reveals a Metabolically Driven Dilated ... Other 2025 Neutral 75
Impact of structured medication reviews on prescribing in English Primary Car... Other 2025 Neutral 75
Vitamin D and Respiratory Diseases : Based on 11th Dr. I. C. Verma Excellence... Review 2024 Mixed 75
Exercise training improves sarcopenic muscle function via restoration of mito... Other 2025 Neutral 70
Temporal genome dynamics of ST39 <i>Klebsiella pneumoniae</i> in a neonatal... Other 2025 Neutral 70
Vitamin D and respiratory health in the Busselton Healthy Ageing Study. Other 2018 Supports 70
Network Analysis Reveals Protein Modules Associated with Childhood Respirator... Other 2024 Supports 65
Canadian Adaptive Platform Trial of Treatments for COVID in Community Setting... Other 2024 Neutral 65
Prenatal vitamin D supplementation and child respiratory health: A systematic... Review 2020 65
WS6 enables scalable <i>ex vivo</i> expansion and gene editing of human basal... Other 2025 Neutral 60
Proteome-wide Mendelian randomization analyses to identify potential therapeu... Other 2025 Neutral 60
Association of Maternal Gestational Vitamin D Supplementation with Respirator... Other 2023 Supports 60
VadK, a Non-Canonical Kinase that Regulates the Methylcitrate Cycle and is Es... Other 2025 Neutral 55
Vitamin D, acute respiratory infections, and Covid-19: the curse of small-siz... Other 2024 Mixed 55
Associations between vitamin D, adiposity, and respiratory symptoms in chroni... Other 2018 55
T cell-microbiome associations captured through T cell receptor convergence a... Other 2025 Neutral 50
Mapping risks of hospital-recorded health conditions in people with eczema Other 2025 Neutral 50
Association between prenatal vitamin D supplementation and respiratory diseas... Meta-analysis 2025 50
Vitamin D and Influenza: Immunological Insights and Therapeutic Potential for... Review 2026 Supports 45
Burst suppression: a default brain state associated with loss of network comp... Other 2025 Neutral 45
Influence of vitamin D supplementation on muscle strength and exercise capaci... Other 2024 Mixed 45
Biological landscape of acute illness in children in sub-Saharan Africa and S... Other 2025 Neutral 40
Micronutrient-deficient diets and possible environmental enteric dysfunction ... Other 2024 Neutral 40
Maternal vitamin D-related metabolome and offspring risk of asthma outcomes. Other 2023 Supports 40
Exercise intensity modulates the human plasma secretome and interorgan commun... Other 2025 Neutral 35
Brain activity as a candidate biomarker for personalised caffeine treatment i... Other 2025 Neutral 35
The effects of prenatal vitamin D supplementation on respiratory and allergy-... Review 2025 35
Artemether and Euphorbia Factor L9 suppress kynurenine production through dis... Other 2025 Neutral 30
Healthcare Costs and Healthcare Utilization Outcomes of Vitamin D3 Supplement... Other 2023 Supports 30
A test of vitamin D benefits on respiratory health mediated through inflammat... Other 2015 Supports 30

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Medical Disclaimer: Noyemi provides information from published research for educational purposes only. This content is not medical advice and does not replace consultation with a qualified healthcare provider. Always consult your doctor before starting, stopping, or changing any supplement regimen, especially if you take medications or have existing health conditions.