Research suggests that vitamin D plays a meaningful role in cardiovascular health through several biological pathways, including regulation of inflammation, oxidative stress, calcium handling, and the renin-angiotensin system, with reviews indicating that deficiency may worsen outcomes in conditions such as heart failure with reduced ejection fraction. A 2024 observational study further found that variations in the vitamin D receptor gene may be associated with differences in heart valve function and hypertension risk, adding a genetic dimension to the conversation. However, the available evidence is mixed: while epidemiological data consistently link low vitamin D levels to poorer cardiac outcomes, randomized controlled trials testing supplementation have produced inconsistent results, and a 2025 methodological study raised important concerns about the reliability of certain statistical approaches used to establish causal relationships between vitamin D and cardiovascular markers like inflammation. Overall, the body of evidence — drawn primarily from reviews and observational studies rather than large, definitive clinical trials — supports the importance of maintaining adequate vitamin D levels for heart health, but stops short of establishing supplementation as a proven therapeutic intervention.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| Pivotal role of vitamin D in mitochondrial health, cardiac function, and huma... | Review | 2022 | Supports | 100 |
| Nutrition in Cardioskeletal Health. | Review | 2016 | Supports | 95 |
| Facilitators and Barriers for the use of Direct Anticoagulant: A qualitative ... | Other | 2025 | Neutral | 90 |
| The interplay between bone and heart health as reflected in medication effect... | Review | 2023 | Mixed | 90 |
| Vitamin D receptor is necessary for metabolic health after sleeve gastrectomy | Other | 2025 | Neutral | 85 |
| Non-linear Mendelian randomization of vitamin D and C-Reactive Protein: an in... | Other | 2025 | Neutral | 85 |
| Role of Vitamin D in Patients with Heart Failure with Reduced Ejection Fraction. | Review | 2019 | Mixed | 85 |
| A <i>Slc5a6</i> Deficient Mouse Model Reveals a Metabolically Driven Dilated ... | Other | 2025 | Neutral | 80 |
| Impact of structured medication reviews on prescribing in English Primary Car... | Other | 2025 | Neutral | 80 |
| Nutrition and Micronutrient Interactions in Autoimmune Thyroid Disorders: Imp... | Review | 2025 | Neutral | 80 |
| Connections between <i>Klebsiella pneumoniae</i> Bloodstream Dynamics and Ser... | Other | 2025 | Neutral | 75 |
| Identifying profiles, trajectories, burden, social and biological factors in ... | Other | 2025 | Neutral | 75 |
| Associations between vitamin D status, VDR gene polymorphisms and echocardiog... | Other | 2024 | Supports | 75 |
| Metabolism of <i>Lactobacillus</i> and <i>Gardnerella vaginalis</i> in vagina... | Other | 2025 | Neutral | 70 |
| Genome-wide association meta-regression identifies stem cell lineage orchestr... | Other | 2025 | Neutral | 70 |
| Prime mover or fellow traveller: 25-hydroxy vitamin D's seasonal variation, c... | Other | 2015 | Mixed | 70 |
| BtuJ1, a novel surface-exposed B<sub>12</sub>-binding protein in <i>Bacteroid... | Other | 2025 | Neutral | 65 |
| Prescription Cascades Associated with Acetylcholinesterase Inhibitors Use: A ... | Other | 2025 | Neutral | 65 |
| Vitamin D deficits may affect heart health. | Other | 2008 | Supports | 65 |
| Paternal over- and under-nutrition program fetal and placental development in... | Other | 2025 | Neutral | 60 |
| Development and external validation of prediction models for major osteoporot... | Other | 2025 | Neutral | 60 |
| Current Trend and Outcomes on Immunonutrition in Medical and Surgical Fields:... | Review | 2024 | Supports | 60 |
| An RNA regulates iron homeostasis and host mucus colonization in <i>Bacteroid... | Other | 2025 | Neutral | 55 |
| Association of Long-Term Outdoor Air Pollution Exposure with Incidence of Par... | Other | 2025 | Neutral | 55 |
| Applying data mining techniques to predict vitamin D deficiency in diabetic p... | Other | 2023 | Neutral | 55 |
| Renal Coenzyme A (CoA) Production Fuels Stem Cell Proliferation and Tumor Growth | Other | 2025 | Neutral | 50 |
| No evidence that retinol is protective for skin cancer | Other | 2024 | Neutral | 50 |
| Your article on the "A-B-C's of heart health" in the October 2008 "Women's He... | Other | 2009 | — | 50 |
| Targeting immunometabolic pathways with AZD1656 alleviates inflammation and m... | Other | 2025 | Neutral | 45 |
| Variants in NR6A1 cause a novel oculo-vertebral-renal (OVR) syndrome | Other | 2024 | Neutral | 45 |
| Supplemental 25-hydroxycholecalciferol Alleviates Inflammation and Cardiac Fi... | Other | 2020 | Supports | 45 |
| The renal response to FGF23 shifts from phosphaturia towards inflammation in ... | Other | 2025 | Neutral | 40 |
| Mapping risks of hospital-recorded health conditions in people with eczema | Other | 2025 | Neutral | 40 |
| Trends and Motivations in Dietary Supplement Use Among People with Diabetes: ... | Other | 2024 | Neutral | 40 |
| Niche partitioning by resource size in the gut microbiome | Other | 2025 | Neutral | 35 |
| Prioritizing protein targets for dyslipidaemia and cardiovascular diseases us... | Other | 2024 | Neutral | 35 |
| Renal osteodystrophy in children: a systemic disease associated with cardiova... | Review | 2006 | Supports | 35 |
| Biological landscape of acute illness in children in sub-Saharan Africa and S... | Other | 2025 | Neutral | 30 |
| Associations between vitamin D and autoimmune diseases: Mendelian randomizati... | Other | 2023 | Neutral | 30 |
| Perceptions of a Healthy Diet: Insights From a 3-Country Survey. | Other | 2015 | Neutral | 30 |