Vitamin B1, also known as thiamine, is a water-soluble essential nutrient that plays a foundational role in energy metabolism by helping convert carbohydrates into usable fuel for the body. Research suggests that thiamine is critical for healthy nerve function, with studies indicating that deficiency can lead to significant neurological and cardiovascular complications, as seen historically in conditions like beriberi and Wernicke-Korsakoff syndrome. Emerging research has also explored thiamine's role in supporting cognitive function, particularly in aging populations and individuals with increased metabolic demands. Available in several supplemental forms — including thiamine hydrochloride, thiamine mononitrate, and benfotiamine, a fat-soluble derivative studied for its enhanced bioavailability — thiamine remains one of the most well-established B vitamins in nutritional science.
Compare this supplementResearch suggests that thiamine (vitamin B1) plays a fundamental role in metabolic processes across a wide range of o...
View studies →Research suggests a possible association between vitamin B1 levels and cognitive function, though the evidence base h...
View studies →Research suggests that thiamine may play a role in modulating inflammatory immune responses that can affect nerve fun...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 100–300 mg | Three times daily | cognitive function and neurological support in deficiency-related conditions | Based on RCTs studying thiamine in Wernicke's encephalopathy and cognitive decline |
| Capsule | 600–1,800 mg | Daily | high-dose thiamine therapy for fatigue and nerve function in chronic conditions | Based on clinical trials by Costantini et al. studying high-dose thiamine in neurological disorders |
| Tablet | 1–2 mg | Daily | general health and dietary reference intake for adults | Based on established RDI/RDA guidelines and standard supplementation trials |
| Tablet | 50–100 mg | Daily | metabolism support and general B-complex supplementation | Common in clinical trials and B-vitamin complex formulations |
| Tablet | 25–50 mg | Daily | nerve function support and peripheral neuropathy prevention | Common in clinical trials for diabetic and alcohol-related neuropathy |