Research suggests that Tongkat Ali (Eurycoma longifolia) may support libido, erectile function, and testosterone levels in men, with the evidence base spanning animal studies, small randomized controlled trials, and several systematic reviews and meta-analyses that generally point in a positive direction. Studies indicate that the herb may work through multiple mechanisms, including testosterone modulation, stress hormone reduction, and — based on laboratory findings — inhibition of enzymes involved in erectile function such as PDE-5 and ROCK-II, though these mechanistic findings have yet to be fully translated into robust clinical evidence. A 2015 meta-analysis pooling data from only two eligible trials found that improvements in erectile function scores did not reach statistical significance overall, though a subgroup analysis hinted at potential benefit in men with lower baseline function, and a 2022 systematic review found a statistically significant testosterone-raising effect in hypogonadal men specifically. Across the literature, limitations are consistent and notable: sample sizes are generally small, study durations are short, methodological quality varies, and a 2019 analysis of popular ED supplements found that the broader evidence base for such ingredients — including tongkat ali — remains thin when scrutinized carefully, meaning confident clinical conclusions cannot yet be drawn.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| Eurycoma longifolia Jack enhances libido in sexually experienced male rats. | Other | 1997 | Supports | 98 |
| Phytoandrogenic properties of Eurycoma longifolia as natural alternative to t... | Review | 2014 | Supports | 90 |
| A 6-month, double-blind, placebo-controlled, randomized trial to evaluate the... | RCT | 2021 | Supports | 88 |
| Efficacy of Tongkat Ali (Eurycoma longifolia) on erectile function improvemen... | Meta-analysis | 2015 | Supports | 85 |
| Effect of Tongkat Ali on stress hormones and psychological mood state in mode... | Other | 2013 | Supports | 85 |
| Asian herbals and aphrodisiacs used for managing ED. | Review | 2017 | Supports | 80 |
| Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Al... | Review | 2016 | Supports | 78 |
| Phosphodiesterase-5 Inhibitory Activity of Canthin-6-One Alkaloids and the Ro... | Other | 2022 | Supports | 75 |
| Rho-Kinase II Inhibitory Potential of Eurycoma longifolia New Isolate for the... | Other | 2019 | Supports | 73 |
| Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A System... | Systematic review | 2022 | Supports | 72 |
| Do "testosterone boosters" really increase serum total testosterone? A system... | Systematic review | 2024 | Supports | 68 |
| A Multifaceted Review of Eurycoma longifolia Nutraceutical Bioactives: Produc... | Review | 2023 | Supports | 65 |
| An Analysis of Popular Online Erectile Dysfunction Supplements. | Systematic review | 2019 | Neutral | 65 |
| Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharm... | Review | 2010 | Supports | 62 |