Research suggests that saffron may offer some benefit for PMS symptom relief, though the evidence remains preliminary and limited. A 2009 systematic review identified saffron as showing only early-stage promise among natural products examined for PMS, noting that the overall body of evidence for most herbal options — saffron included — was insufficient to draw firm conclusions, with calcium being the only intervention supported by strong evidence at that time. More recently, a randomized controlled trial found significant symptom reductions with a multi-ingredient supplement containing saffron alongside numerous other compounds, though this design makes it impossible to attribute any benefit specifically to saffron itself. Studies indicate that while the directional signal is cautiously positive, the lack of saffron-specific trials, small sample sizes, and methodological variability across existing research mean that stronger, well-designed studies are needed before conclusions can be drawn about its effectiveness as a standalone intervention for PMS.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| Natural relief for premenstrual syndrome (PMS): a double-blind clinical trial... | Other | 2025 | Supports | 72 |
| Herbs, vitamins and minerals in the treatment of premenstrual syndrome: a sys... | Systematic review | 2009 | Mixed | 67 |