Research suggests that pumpkin seed preparations — including whole seeds, seed oils, and extracts — may support urinary tract health across several conditions, with studies reporting improvements in overactive bladder symptoms, urinary incontinence, lower urinary tract symptoms associated with benign prostatic hyperplasia, and potentially reduced urinary stone risk. The body of evidence includes multiple randomized controlled trials alongside smaller observational and pilot studies, and the overall direction is consistently positive, with participants in most studies reporting reductions in urination frequency, leakage episodes, and symptom severity scores, as well as improvements in quality of life. Studies indicate that both men and women may benefit depending on the condition studied, and pumpkin seed preparations were generally well tolerated across trials, with one RCT suggesting a multi-ingredient supplement containing pumpkin seed extract compared favorably to a prescription anticholinergic drug in terms of both symptom relief and side effect profile. However, important limitations apply throughout this literature: many studies lack placebo control groups, several involve multi-ingredient supplements that make it difficult to isolate pumpkin seeds' specific contribution, sample sizes are frequently small, and the multi-ingredient formulations vary considerably across trials, meaning the overall evidence — while encouraging — should be considered preliminary and in need of larger, more rigorous confirmatory research.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| Cucurbita pepo-Rhus aromatica-Humulus lupulus Combination Reduces Overactive ... | RCT | 2019 | Supports | 97 |
| Pumpkin Seed Oil Extracted From Cucurbita maxima Improves Urinary Disorder in... | Other | 2014 | Supports | 97 |
| Clinical study of effectiveness and safety of CELcomplex(®) containing Cucurb... | Other | 2019 | Supports | 95 |
| Effects of an Oil-Free Hydroethanolic Pumpkin Seed Extract on Symptom Frequen... | RCT | 2019 | Supports | 93 |
| Evaluation of Femaxeen® for control of urinary incontinence in women: A rando... | RCT | 2020 | Supports | 90 |
| Effects of pumpkin seed in men with lower urinary tract symptoms due to benig... | RCT | 2015 | Supports | 88 |
| Extract from Cucurbita pepo improves BPH symptoms without affecting sexual fu... | Other | 2022 | Supports | 87 |
| Prospective Multicenter Open-Label One-Arm Trial Investigating a Pumpkin Seed... | Other | 2020 | Supports | 85 |
| Profiling Hydrophilic Cucurbita pepo Seed Extracts: A Study of European Culti... | Other | 2025 | Supports | 82 |
| A randomized, multicenter, controlled study, comparing efficacy and safety of... | RCT | 2017 | Supports | 82 |
| Outcomes of a complementary and alternative medicine based on vitamins, herba... | Other | 2022 | Supports | 80 |
| The effect of pumpkin seeds on oxalcrystalluria and urinary compositions of c... | RCT | 1987 | Supports | 78 |
| Deciphering Multi-target Pharmacological Mechanism of Cucurbita pepo Seeds ag... | Other | 2024 | Supports | 75 |
| Effects of a Supplement Containing a Cranberry Extract on Recurrent Urinary T... | Other | 2022 | Supports | 72 |
| Pumpkin seed extract: Cell growth inhibition of hyperplastic and cancer cells... | Other | 2016 | Supports | 62 |