Pumpkin Seeds for Urinary Tract Health

Strong evidence 15 studies

Research suggests that pumpkin seed preparations — including whole seeds, seed oils, and extracts — may support urinary tract health across several conditions, with studies reporting improvements in overactive bladder symptoms, urinary incontinence, lower urinary tract symptoms associated with benign prostatic hyperplasia, and potentially reduced urinary stone risk. The body of evidence includes multiple randomized controlled trials alongside smaller observational and pilot studies, and the overall direction is consistently positive, with participants in most studies reporting reductions in urination frequency, leakage episodes, and symptom severity scores, as well as improvements in quality of life. Studies indicate that both men and women may benefit depending on the condition studied, and pumpkin seed preparations were generally well tolerated across trials, with one RCT suggesting a multi-ingredient supplement containing pumpkin seed extract compared favorably to a prescription anticholinergic drug in terms of both symptom relief and side effect profile. However, important limitations apply throughout this literature: many studies lack placebo control groups, several involve multi-ingredient supplements that make it difficult to isolate pumpkin seeds' specific contribution, sample sizes are frequently small, and the multi-ingredient formulations vary considerably across trials, meaning the overall evidence — while encouraging — should be considered preliminary and in need of larger, more rigorous confirmatory research.

Related studies

Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.

Title Type Year Direction Match
Cucurbita pepo-Rhus aromatica-Humulus lupulus Combination Reduces Overactive ... RCT 2019 Supports 97
Pumpkin Seed Oil Extracted From Cucurbita maxima Improves Urinary Disorder in... Other 2014 Supports 97
Clinical study of effectiveness and safety of CELcomplex(®) containing Cucurb... Other 2019 Supports 95
Effects of an Oil-Free Hydroethanolic Pumpkin Seed Extract on Symptom Frequen... RCT 2019 Supports 93
Evaluation of Femaxeen® for control of urinary incontinence in women: A rando... RCT 2020 Supports 90
Effects of pumpkin seed in men with lower urinary tract symptoms due to benig... RCT 2015 Supports 88
Extract from Cucurbita pepo improves BPH symptoms without affecting sexual fu... Other 2022 Supports 87
Prospective Multicenter Open-Label One-Arm Trial Investigating a Pumpkin Seed... Other 2020 Supports 85
Profiling Hydrophilic Cucurbita pepo Seed Extracts: A Study of European Culti... Other 2025 Supports 82
A randomized, multicenter, controlled study, comparing efficacy and safety of... RCT 2017 Supports 82
Outcomes of a complementary and alternative medicine based on vitamins, herba... Other 2022 Supports 80
The effect of pumpkin seeds on oxalcrystalluria and urinary compositions of c... RCT 1987 Supports 78
Deciphering Multi-target Pharmacological Mechanism of Cucurbita pepo Seeds ag... Other 2024 Supports 75
Effects of a Supplement Containing a Cranberry Extract on Recurrent Urinary T... Other 2022 Supports 72
Pumpkin seed extract: Cell growth inhibition of hyperplastic and cancer cells... Other 2016 Supports 62

← Back to Pumpkin Seeds

Medical Disclaimer: Noyemi provides information from published research for educational purposes only. This content is not medical advice and does not replace consultation with a qualified healthcare provider. Always consult your doctor before starting, stopping, or changing any supplement regimen, especially if you take medications or have existing health conditions.
Affiliate Disclosure: As an Amazon Associate, Noyemi earns from qualifying purchases. Product links on this site may generate a small commission at no extra cost to you.