Phellodendron amurense, commonly known as Amur cork tree, has a long history of use in traditional East Asian medicine, with modern research beginning to explore several of its potential benefits. Studies indicate that berberine and other alkaloids found in the bark may contribute to anti-inflammatory activity, with some preliminary research suggesting effects on markers associated with joint discomfort and general inflammation. Research also suggests that Phellodendron bark extract, particularly when combined with Magnolia officinalis, may help support healthy cortisol levels related to stress, which in turn has been studied for its possible role in weight management linked to stress-related overeating. While these early findings are promising, much of the evidence comes from small or short-term studies, and further research is needed to better understand its full range of effects.
Compare this supplementResearch suggests that Phellodendron bark and its bioactive compounds — most notably the alkaloid berberine and the l...
View studies →Research suggests that Phellodendron, when combined with Magnolia officinalis in a proprietary blend, may help limit ...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 400–500 mg | Twice daily | joint inflammation and osteoarthritis | Used in trials assessing NF-kB pathway modulation and joint comfort outcomes |
| Extract | 500–1,000 mg | Daily | anti-inflammatory and antimicrobial support | Common in clinical and preclinical studies on berberine-containing Phellodendron bark extract |
| Extract | 200–400 mg | Daily | stress relief and cortisol modulation | Used in clinical trials examining HPA axis and stress response, often as Relora (combination with Magnolia) |
| Extract | 200–400 mg | Daily | weight management and metabolic support | Studied as part of Relora combination formula in weight management RCTs |