Pelargonium (Umckaloabo) for Cold And Flu Support

Strong evidence 17 studies

Research suggests that Pelargonium sidoides extract (commonly marketed as Umckaloabo, standardized as EPs 7630) may help reduce the severity and duration of symptoms associated with the common cold, acute bronchitis, and other upper respiratory tract infections, with the body of evidence drawing from multiple randomized controlled trials, several Cochrane systematic reviews, and more recent network meta-analyses — nearly all pointing in a supportive direction. Studies indicate that the liquid form of the extract appears more consistently effective than tablet formulations, and a 2023 network meta-analysis rated Pelargonium sidoides as offering the most beneficial effect on common cold symptom improvement among the herbal options studied, with moderate certainty of evidence. However, reviewers across multiple Cochrane analyses have cautioned that overall evidence quality ranges from low to very low due to concerns about study methodology, publication bias, and variability in how outcomes were measured, meaning the positive findings should be interpreted with appropriate caution. Side effects were reported more frequently with Pelargonium sidoides than with placebo in some trials, though none were characterized as serious, and no studies reviewed here were evaluating it as a cure or replacement for conventional medical care.

Related studies

Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.

Title Type Year Direction Match
Efficacy and Tolerability of High-dose Pelargonium Extract in Patients With t... RCT 2018 Supports 95
Pelargonium sidoides extract for treating acute respiratory tract infections. Meta-analysis 2013 Supports 95
Pelargonium sidoides extract for acute respiratory tract infections. Systematic review 2008 Supports 95
Herbal Medicines for Rhinosinusitis: A Systematic Review and Network Meta-ana... Meta-analysis 2023 Supports 90
Herbal Medicine for Cough: a Systematic Review and Meta-Analysis. Meta-analysis 2015 Supports 88
Treatment of the common cold in children and adults. Review 2012 Supports 85
Diagnosis and treatment of acute bronchitis. Review 2010 Supports 82
[Pelargonium sidoides-extract (EPs 7630): registration confirms efficacy and ... Review 2007 Supports 82
Complementary and alternative medicine in the treatment of acute bronchitis i... Systematic review 2020 Supports 80
Pelargonium sidoides for acute bronchitis: a systematic review and meta-analy... Meta-analysis 2008 Supports 80
A historical, scientific and commercial perspective on the medicinal use of P... Review 2008 Supports 75
EPs(®) 7630 Stimulates Tissue Repair Mechanisms and Modifies Tight Junction P... Other 2023 Supports 70
Non-pharmacological remedies for post-viral acute cough. Other 2021 Supports 65
Benefits, pitfalls and risks of phytotherapy in clinical practice in otorhino... Review 2017 Supports 65
Natural remedies for acute post-viral cough in children. Review 2021 Supports 62
Hand, foot, and mouth disease: could EPs® 7630 be a treatment option? A prosp... Other 2024 Supports 60
Stevens' Cure (Umckaloabo)-the vindication of a patent medicine. Other 2023 Supports 60

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Medical Disclaimer: Noyemi provides information from published research for educational purposes only. This content is not medical advice and does not replace consultation with a qualified healthcare provider. Always consult your doctor before starting, stopping, or changing any supplement regimen, especially if you take medications or have existing health conditions.