Research suggests that pea protein may support appetite regulation and weight management through several biological mechanisms, including stimulating the release of satiety hormones such as cholecystokinin (CCK) and glucagon-like peptide 1 (GLP-1) from intestinal tissue. Studies indicate that partially digested forms of pea protein, known as hydrolysates, may also slow gastric emptying and influence hunger-related hormones like ghrelin, with one small randomized controlled trial in overweight men finding that a pea protein hydrolysate reduced calorie intake at a subsequent meal by roughly 126 calories. The available evidence comes primarily from laboratory tissue studies and a single small clinical trial, which limits how confidently findings can be applied to broader populations, and one lab study found that pea protein hydrolysates did not directly activate the CCK receptor the way soy protein hydrolysates did, suggesting pea protein's satiety effects may be more limited in certain respects. Overall, the research is preliminary and directionally promising but not yet sufficient to draw firm conclusions about pea protein's practical role in weight management for the general population.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| Protein hydrolysates induce CCK release from enteroendocrine cells and act as... | Other | 2008 | Mixed | 100 |
| Release of satiety hormones in response to specific dietary proteins is diffe... | Other | 2010 | Supports | 95 |
| Randomized Controlled Trial: Effects of a Bitter-Tasting Pea Protein Hydrolys... | RCT | 2025 | Supports | 90 |
| Identification of significant genome-wide associations and QTL underlying var... | Other | 2024 | — | 85 |
| Advancing RNAi-Based Strategies Against Downy Mildews: Insights Into dsRNA Up... | Other | 2025 | — | 80 |
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| Chromosome-level Assemblies of Three Candidatus Liberibacter solanacearum Vec... | Other | 2024 | — | 70 |
| Biosynthesis and Bioactivity of Anti-Inflammatory Triterpenoids in <i>Calendu... | Other | 2025 | Neutral | 65 |
| Chromosome scale genomes of two invasive Adelges species enable virtual scree... | Other | 2024 | — | 60 |
| Genomic insights into clonal diversity in UK populations of the Potato aphid,... | Other | 2023 | — | 55 |
| Immune Correlates of Hyperglycemia and Vaccination in a Non-human Primate Mod... | Other | 2023 | — | 50 |
| The chloroplastic phosphate transporter CrPHT4-7 supports phosphate homeostas... | Other | 2023 | — | 45 |
| An improved<i>Nicotiana benthamiana</i>bioproduction chassis provides novel i... | Other | 2023 | Neutral | 40 |
| Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Traj... | Other | 2020 | — | 35 |