The studies provided do not contain research relevant to papain and digestive health. The linked studies investigate topics related to SARS-CoV-2 genomics, COVID-19 treatments such as ensitrelvir and simeprevir, coronavirus molecular mechanisms including the papain-like protease as a viral enzyme target, and COVID-19 outcomes in specific patient populations. While one study does examine the papain-like protease of SARS-CoV-2, this refers to a viral enzyme involved in immune evasion and is entirely unrelated to papain as a dietary supplement or its effects on human digestion. As a result, no evidence-based summary about papain and digestive health can be responsibly synthesized from the materials provided, and any such summary would misrepresent what these studies actually investigated.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| Assessing the impact of SARS-CoV-2 lineages and mutations on patient survival | Other | 2022 | Neutral | 90 |
| Urine proteomic characterization of active and recovered COVID-19 patients | Other | 2023 | Neutral | 85 |
| Disulfiram associated with lower risk of Covid-19: a retrospective cohort study | Other | 2021 | Neutral | 85 |
| The papain-like protease of coronaviruses cleaves ULK1 to disrupt host autophagy | Other | 2020 | Neutral | 80 |
| COVID-19 and Inflammatory Bowel Diseases: risk assessment, shared molecular p... | Other | 2020 | Neutral | 80 |
| Efficacy and Safety of 5-Day Oral Ensitrelvir for Patients With Mild-to-Moder... | Other | 2023 | Neutral | 75 |
| Simeprevir potently suppresses SARS-CoV-2 replication and synergizes with rem... | Other | 2020 | Neutral | 75 |
| A Randomized Phase 2/3 Study of Ensitrelvir, a Novel Oral SARS-CoV-2 3C-like ... | Other | 2022 | Neutral | 70 |
| The IMEx Coronavirus interactome: an evolving map of Coronaviridae-Host molec... | Other | 2020 | Neutral | 70 |
| A Phase 2/3 study of S-217622 in participants with SARS-CoV-2 infection (Phas... | Other | 2022 | Neutral | 65 |
| Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential ... | Other | 2020 | Neutral | 65 |
| Two independent introductions of SARS-CoV-2 into the Iranian outbreak | Other | 2020 | Neutral | 60 |