Nicotinamide Mononucleotide (NMN) is a naturally occurring compound and a direct precursor to NAD+, a coenzyme essential for cellular energy production, DNA repair, and numerous metabolic processes. Research suggests that NAD+ levels decline with age, and supplementing with NMN may help support the body's ability to maintain healthy NAD+ levels, which has generated significant interest in the longevity and healthy-aging space. Studies indicate that NMN supplementation in animal models has shown promising effects on metabolism, cardiovascular function, cognitive health, and exercise capacity, with emerging human trials beginning to explore similar outcomes. Available commonly in capsule and sublingual forms for potentially enhanced absorption, NMN continues to be an active and evolving area of scientific investigation into cellular health and age-related metabolic changes.
Compare this supplementResearch suggests that NMN has attracted scientific interest primarily as a NAD⁺ precursor with potential relevance t...
View studies →Research suggests that NMN and related NAD-pathway molecules play complex and context-dependent roles in cell health,...
View studies →Research suggests that NMN, as a precursor to NAD⁺, plays a meaningful role in cellular energy metabolism, though the...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 600–900 mg | Daily | Exercise performance and cardiovascular function in older adults | Studied in higher-dose RCTs for older adults (Huang et al., 2022) |
| Capsule | 250–300 mg | Daily | General anti-aging and metabolic support | Common in early human clinical trials (Yoshino et al., 2021; Irie et al., 2020) |
| Capsule | 500 mg | Daily | NAD+ elevation, metabolism support, and muscle function | Used in RCTs assessing NAD+ bioavailability and physical performance (Canto et al.; Liao et al., 2021) |
| Powder | 250–500 mg | Daily | Cognitive function and cell health | Dose range used in human trials examining NAD+ precursor supplementation |
| Tablet | 1,000–1,200 mg | Daily | Maximum studied doses for NAD+ optimization and anti-aging research | Higher-dose safety and tolerability trials (Mills et al., 2016 mouse basis; human safety trials up to 1200 mg) |