Myo-Inositol for Sleep Quality

Research suggests a mixed and largely preliminary picture when it comes to myo-inositol and sleep quality. The most direct clinical evidence comes from a single small randomized controlled trial in pregnant women, which found modest improvements in self-reported sleep quality with myo-inositol supplementation compared to placebo, though the sample size and specific population limit how broadly these findings can be applied. Several observational and neuroimaging studies — none of which tested myo-inositol as a supplement — measured myo-inositol as a brain metabolite and found it elevated in conditions associated with poor sleep, neuroinflammation, and glial cell activity, such as obstructive sleep apnea and aging-related sleep disturbance, suggesting that higher brain myo-inositol levels may reflect underlying tissue changes rather than a beneficial effect. Overall, the evidence base is small, methodologically varied, and insufficient to draw firm conclusions about whether myo-inositol supplementation meaningfully improves sleep in the general population.