Milk thistle has been used for centuries as a traditional remedy for liver-related concerns, and modern research continues to explore its potential. The active compound, silymarin — a group of flavonolignans with silybin as its most potent component — has been studied extensively for its antioxidant and anti-inflammatory properties. Research suggests that silymarin may support liver health by helping protect liver cells from oxidative stress and promoting cellular repair processes. Studies also indicate emerging interest in its potential benefits for skin health, where its antioxidant activity may help defend against environmental damage. Milk thistle is commonly available as a standardized extract containing 80% silymarin or as Siliphos, a silybin phytosome formulation designed to enhance absorption. While findings are promising, research remains ongoing and results can vary across studies.
Compare this supplementResearch suggests that silymarin, the active compound in milk thistle, shows promise for liver health through its abi...
View studies →Research suggests that the available evidence directly examining milk thistle for skin health is very limited, with t...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 140 mg | Three times daily | liver cirrhosis, chronic hepatitis support | Classic silymarin dosing regimen used in European clinical research (Legalon) |
| Extract | 160–800 mg | Daily | chemotherapy-induced hepatotoxicity, liver protection during drug therapy | Range observed across oncology and hepatology RCTs using silymarin |
| Extract | 140–420 mg | Daily | liver health, hepatoprotection, chronic liver disease | Common in clinical trials using standardized silymarin (70-80%) extract |
| Extract | 420–600 mg | Daily | non-alcoholic fatty liver disease (NAFLD), liver enzyme reduction | Based on RCTs studying silymarin in NAFLD patients |
| Extract | 210–420 mg | Daily | type 2 diabetes with liver involvement, oxidative stress reduction | Dose range used in RCTs examining glycemic and hepatic outcomes |
| Topical | 0.5–1.5 g | Daily | skin health, acne, anti-inflammatory and antioxidant skin effects | Based on limited clinical studies and topical formulation research |