Research suggests that mastic gum may help reduce heartburn and related symptoms, with two randomized controlled trials conducted in 2010 and 2025 both reporting significant improvements in heartburn and epigastric burning among patients with functional dyspepsia. A third study examined abdominal massage using mastic gum oil for gastroesophageal reflux symptoms in infants, broadening the range of populations and delivery methods explored. Studies indicate a generally supportive direction across this small body of evidence, though the total number of trials remains limited, and findings specific to classical acid reflux or GERD in adults are less directly addressed. Readers should note that a small number of studies, even when well-designed as RCTs, is not sufficient to draw firm conclusions, and further independent replication would strengthen confidence in these preliminary findings.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| Is Chios mastic gum effective in the treatment of functional dyspepsia? A pro... | RCT | 2010 | Supports | 90 |
| A randomized, three-way crossover clinical trial on the efficacy of Mastiha b... | RCT | 2025 | Supports | 88 |
| Efficacy of abdominal massage with mastic gum oil on gastroesophageal reflux ... | Other | 2020 | Supports | 85 |