L-Lysine is an essential amino acid, meaning the body cannot produce it on its own and must obtain it through diet or supplementation. Research suggests that L-lysine may play a supportive role in several areas of health, with some of the most well-known studies focusing on its potential to reduce the frequency and severity of cold sore outbreaks caused by herpes simplex virus. Studies also indicate that lysine contributes to collagen synthesis, which is important for wound healing, skin integrity, and connective tissue maintenance. Additionally, preliminary research has explored its role in calcium absorption and its potential to help modulate the body's stress response, with some evidence suggesting it may support reduced anxiety, particularly when combined with L-arginine.
Compare this supplementResearch suggests that L-Lysine plays a recognized biochemical role in collagen synthesis, primarily as a substrate f...
View studies →Research suggests that the evidence base for L-lysine specifically as a nutrient absorption aid is limited within the...
View studies →Research suggests that L-lysine and lysine-containing compounds are associated with wound healing through several dis...
View studies →The single study linked here does not investigate L-Lysine or anxiety in any form; it examines antipsychotic drugs an...
View studies →The single study linked here does not investigate L-Lysine or cold sore treatment in any way; it examines astrocyte m...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 1,000–3,000 mg | Daily | cold sore treatment and herpes simplex virus suppression | Based on RCTs studying lysine for HSV recurrence reduction |
| Capsule | 500–1,000 mg | Daily | general health and nutrient absorption | Common in clinical trials and supplementation studies |
| Capsule | 1,000–2,000 mg | Daily | wound healing and tissue repair | Referenced in clinical literature on amino acid support for healing |
| Powder | 1,000–2,000 mg | Daily | collagen synthesis and connective tissue support | Common in studies on lysine as a cofactor in collagen cross-linking |
| Tablet | 500–1,500 mg | Daily | anxiety relief and stress reduction | Based on clinical trials examining lysine and arginine combination for anxiety |
| Topical | — | As needed | cold sore treatment applied directly to lesions | Used in topical cream formulations studied for oral herpes lesions |