L-Citrulline is a non-essential amino acid naturally produced in the body and found in foods like watermelon, where it was first identified and from which it takes its name. Once consumed, it is efficiently converted to L-arginine in the kidneys, which in turn supports the production of nitric oxide — a molecule that helps relax and widen blood vessels. Research suggests that this pathway may contribute to improved blood circulation, healthier blood pressure levels, and enhanced exercise performance by supporting oxygen and nutrient delivery to working muscles. Studies also indicate potential benefits for muscle recovery after intense physical activity and for supporting aspects of sexual health related to vascular function. L-citrulline is commonly available on its own or bonded with malic acid as citrulline malate, a form frequently studied in exercise-related research.
Compare this supplementResearch suggests that L-citrulline supplementation may offer modest benefits for exercise performance, particularly ...
View studies →Research suggests that L-citrulline may support blood circulation primarily by increasing plasma L-arginine levels an...
View studies →Research suggests that l-citrulline may support blood pressure regulation primarily through its role as a precursor t...
View studies →Research suggests that L-citrulline has been studied primarily as a biological marker of inflammation and oxidative s...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 1.5–3 g | Daily | Libido and sexual function | Doses used in RCTs examining erectile function and sexual health outcomes |
| Powder | 8 g | As needed | Acute exercise performance and muscle recovery | Single pre-exercise dose studied in resistance and endurance training trials |
| Powder | 2–3 g | Three times daily | Blood circulation and nitric oxide production | Split dosing protocol used in multiple clinical trials to sustain plasma arginine levels |
| Powder | 3–6 g | Daily | Blood pressure regulation and cardiovascular health | Based on RCTs examining arterial stiffness and blood pressure outcomes |
| Powder | 6–8 g | Daily | Exercise performance and muscle recovery | Common in clinical trials studying acute exercise and endurance performance |