Research suggests that Mucuna pruriens may support testosterone levels and broader male reproductive health, with the available evidence drawing largely from animal studies conducted across a range of models including rats, mice, quail, and fish, alongside one human randomized controlled trial examining infertile men. The single human RCT reported improvements in testosterone, LH, and catecholamine levels alongside sperm count and motility following treatment, while the numerous animal studies consistently point in a supportive direction, with several identifying potential mechanisms involving steroidogenic proteins such as StAR and CYP11A1 that are involved in testosterone biosynthesis. Studies indicate that benefits have been observed across various conditions including aging, chronic stress, diabetes, hypercholesterolemia, and chemically induced hormonal disruption, though one animal study introduced a note of caution by finding that higher doses were associated with oxidative stress and testicular tissue damage, suggesting that more may not always be better. The overall body of evidence is encouraging but limited in its direct applicability to humans, as the preponderance of studies are animal-based, and the single human trial focused specifically on infertile men rather than the general population, leaving meaningful gaps that would require well-designed human clinical trials to address.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| Mucuna pruriens improves male fertility by its action on the hypothalamus-pit... | RCT | 2009 | Supports | 97 |
| Aging induced testicular damage: analyzing the ameliorative potential of Mucu... | Other | 2023 | Supports | 93 |
| Seed extract of Thai Mucuna pruriens reduced male reproductive damage in rats... | Other | 2022 | Supports | 92 |
| Mucuna pruriens seed repeals the hypothalamic-pituitary-testicular axis disru... | Other | 2023 | Supports | 90 |
| Protective effects of Thai Mucuna pruriens (L.) DC. var. pruriens seeds on se... | Other | 2022 | Supports | 90 |
| Therapeutic potential of Mucuna pruriens (Linn.) on high-fat diet-induced tes... | Other | 2022 | Supports | 90 |
| Mucuna pruriens seed powder feeding influences reproductive conditions and de... | Other | 2009 | Supports | 90 |
| Assessment of reproductive function in male albino rat fed dietary meal suppl... | Other | 2019 | Mixed | 88 |
| Mucuna pruriens and its major constituent L-DOPA recover spermatogenic loss b... | Other | 2013 | Supports | 88 |
| Traditional formulation-Vanari Gutika treatment improves the testosterone bio... | Other | 2025 | Supports | 87 |
| In vivo evaluation of medicinal effects of Myristica fragrans, Cinnamomum zey... | Other | 2024 | Supports | 83 |
| Comparable to 17α- methyl testosterone, dietary supplements of Tribulus terre... | Other | 2024 | Supports | 82 |
| Mucuna pruriens seeds extract boosts growth, immunity, testicular histology, ... | Other | 2022 | Supports | 82 |
| Effect of Mucuna pruriens (Linn.) on sexual behavior and sperm parameters in ... | Other | 2012 | Supports | 82 |
| Seed extract of Thai Mucuna pruriens (L.) DC. var. pruriens enhances sexual p... | Other | 2022 | Supports | 80 |
| Beyond tribulus (Tribulus terrestris L.): The effects of phytotherapics on te... | Review | 2019 | Supports | 80 |
| Therapeutic potential of Mucuna pruriens (Linn.) on ageing induced damage in ... | Other | 2020 | Supports | 72 |
| Ameliorating effect of Mucuna pruriens seed extract on sodium arsenite-induce... | Other | 2023 | Supports | 70 |
| Antioxidant activity of Flemingia praecox and Mucuna pruriens and their impli... | Other | 2023 | Supports | 70 |
| Prevention of seminal vesicle damage by Mucuna pruriens var. pruriens seed ex... | Other | 2023 | Supports | 68 |
| A Systematic Review on Use of Medicinal Plants for Male Infertility Treatment. | Review | 2021 | Supports | 65 |
| Plants in the management of male infertility. | Review | 2020 | Supports | 65 |
| Restorative effects of Thai Mucuna pruriens seed extract on reproductive, hor... | Other | 2026 | Supports | 62 |