Jiaogulan (Gynostemma pentaphyllum) is a climbing vine used for centuries in traditional Chinese and Southeast Asian herbalism, sometimes called the "immortality herb" due to its association with longevity in regions where it is regularly consumed as tea. Research suggests that its rich profile of saponins called gypenosides may contribute to antioxidant activity, with studies indicating potential benefits for blood sugar regulation, cholesterol management, and adaptive stress response. Preliminary research has also explored its role in supporting immune function and cellular health, though much of the evidence comes from animal or small-scale human studies. Often enjoyed as a mildly sweet herbal tea or taken as a standardized extract, jiaogulan continues to attract scientific interest as researchers work to better understand its mechanisms and long-term effects.
Compare this supplementResearch suggests that Gynostemma pentaphyllum, the plant commonly known as Jiaogulan, may offer anti-aging effects t...
View studies →Research suggests that Gynostemma pentaphyllum demonstrates meaningful antioxidant activity across a range of laborat...
View studies →Research suggests that jiaogulan (Gynostemma pentaphyllum) and its primary active compounds, gypenosides, may support...
View studies →The studies provided in this collection do not appear to contain any research on Jiaogulan or its effects on stress r...
View studies →Research suggests that jiaogulan (Gynostemma pentaphyllum) and its active compounds, gypenosides, may help reduce tot...
View studies →Research on Jiaogulan and immune function is extremely limited based on the available evidence, and the single study ...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Extract | 450–810 mg | Daily | blood sugar regulation and insulin sensitivity | Based on RCTs examining gynostemma pentaphyllum extract in type 2 diabetes patients |
| Extract | 400–800 mg | Daily | cholesterol management and lipid profile improvement | Common in clinical trials targeting LDL and triglyceride reduction |
| Extract | 500–1,000 mg | Daily | immune function and anti-aging support | Common in clinical trials assessing gypenosides' immunomodulatory effects |
| Extract | 225–450 mg | Daily | stress relief and adaptogenic support | Based on clinical studies examining cortisol modulation and adaptogenic activity |
| Tea | 2–3 g | Twice daily | antioxidant support and general health | Traditional use and observational studies in Chinese medicine |