Indole-3-Carbinol (I3C) is a naturally occurring compound found in cruciferous vegetables such as broccoli, cabbage, and Brussels sprouts, formed when these plants are chopped or chewed and their glucosinolates break down. Research suggests that I3C may support the body's natural detoxification processes and play a role in promoting healthy estrogen metabolism, as it appears to influence the pathways by which the body processes and balances certain hormones. Studies indicate that once consumed, I3C is further converted in the stomach to related compounds like diindolylmethane (DIM), which may also contribute to its observed biological activity. While the body of research continues to grow, I3C has drawn considerable interest from scientists exploring its potential role in metabolic and hormonal health.
Compare this supplementResearch suggests that indole-3-carbinol (I3C) plays a meaningful role in supporting the body's detoxification system...
View studies →Research suggests that Indole-3-Carbinol, through its role as an activator of the aryl hydrocarbon receptor (AHR), in...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 400–800 mg | Daily | cervical dysplasia, HPV-related conditions | Used in RCTs investigating regression of cervical intraepithelial neoplasia (CIN) |
| Capsule | 200 mg | Twice daily | estrogen metabolism, 2-OHE1/16α-OHE1 ratio improvement | Dosing regimen used in trials assessing urinary estrogen metabolite ratios |
| Capsule | 200–400 mg | Daily | general health, hormonal balance, detoxification support | Common range used in multiple clinical trials on estrogen metabolism and cancer risk reduction |
| Capsule | 300–400 mg | Daily | recurrent respiratory papillomatosis, laryngeal papillomas | Used in clinical studies as adjunct therapy for HPV-driven papilloma conditions |
| Capsule | 6–12 mg | Daily | weight-based dosing, cancer chemoprevention research | Weight-adjusted dosing (mg/kg) used in some pharmacokinetic and chemoprevention trials |