Graviola, commonly known as soursop, comes from the tropical tree Annona muricata and has a long history of use in traditional medicine across Central and South America, Africa, and Southeast Asia. Research suggests that compounds found in graviola leaves and fruit, particularly acetogenins and various polyphenols, may exhibit anti-inflammatory, antimicrobial, and immune-supporting properties in laboratory and animal studies. Some preliminary research has also explored its potential role in reducing cancer risk at the cellular level, though human clinical trials remain limited and more evidence is needed before drawing firm conclusions. Studies indicate that traditional preparations of the leaf have been used to promote relaxation and sleep quality, and early research offers some support for these calming effects, though the mechanisms are still being investigated.
Compare this supplementResearch suggests that graviola (Annona muricata) may possess anti-inflammatory and antioxidant properties based on a...
View studies →Research suggests that graviola (Annona muricata) possesses antimicrobial and broader bioactive properties attributab...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Extract | 1,000–2,000 mg | Daily | anti-inflammatory and antimicrobial properties | Based on in vitro and animal model research translated to human supplement dosing; formal RCT data limited |
| Extract | 500–1,000 mg | Daily | general health and immune function support | Common in available human studies and standardized extract products; limited robust clinical trial data |
| Leaf extract | 250–500 mg | Twice daily | cancer risk reduction and antioxidant support | Derived from preclinical studies on acetogenin content; human clinical trial evidence remains sparse |
| Powder | 2–4 g | Daily | general health and immune function | Traditional use and observational studies; limited controlled clinical trial basis |
| Tea (leaf infusion) | 1–2 g | Daily | sleep quality and relaxation | Traditional ethnobotanical use in Caribbean and Latin American folk medicine |