Goji Berry (Tcm) for Immune Function

Research suggests that goji berry has a long history of use in Traditional Chinese Medicine for immune support, and a 2021 narrative review found that its nutritional profile — including vitamin C, zinc, selenium, and various bioactive compounds — provides a plausible biological basis for some of these traditional claims. The remaining studies in this set are more tangentially related to immune function: a computational study identified wolfberry as one of many TCM herbs that may theoretically target genes involved in immune cell activity in osteoarthritis, and a small phase I human trial examined a multi-herb formula containing wolfberry for an unrelated condition, with findings suggesting possible effects on the hypothalamic-pituitary-adrenal axis and energy metabolism rather than immune function directly. The overall evidence base for goji berry and immune function specifically remains preliminary, consisting largely of a narrative review and indirect computational predictions rather than controlled clinical trials designed to test immune outcomes. Readers should be aware that the absence of direct human trial data on this specific question means the research, while directionally supportive, does not yet establish clear clinical conclusions.