Research suggests that folate, along with other key nutrients, may play a role in supporting eye health, particularly in relation to conditions such as cataracts and age-related macular degeneration, as highlighted in a 2023 comprehensive review that examined how nutrient deficiencies can contribute to a range of ocular conditions. Studies also indicate that folate's ability to help lower homocysteine levels may be relevant to eye health, given that elevated homocysteine has been associated with various disease processes, though the available evidence on this connection comes primarily from reviews focused on cardiovascular and kidney outcomes rather than ocular endpoints specifically. The body of evidence reviewed here consists entirely of review articles rather than randomized controlled trials or meta-analyses focused on folate and eye health directly, which limits the strength of conclusions that can be drawn. The authors of the relevant reviews consistently noted the need for more targeted long-term studies and personalized nutritional research before stronger claims about folate's role in preserving vision can be made.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| Biomarkers of Nutrition for Development (BOND)-Vitamin A Review. | Review | 2016 | Neutral | 100 |
| Unveiling the Spectrum of Ophthalmic Manifestations in Nutritional Deficienci... | Review | 2023 | Supports | 95 |
| Homocysteine, Vitamin B12 and Folate Level: Possible Risk Factors in the Prog... | Other | 2023 | Neutral | 90 |