Fisetin

Amino Acids & Compounds

Fisetin is a naturally occurring flavonoid found in various fruits and vegetables, with strawberries being among the richest dietary sources. Research suggests that fisetin possesses notable antioxidant and anti-inflammatory properties, and it has attracted growing scientific interest for its potential role in cellular senescence, the process by which aging cells accumulate and contribute to age-related decline. Studies indicate that fisetin may support cognitive function by helping to maintain healthy neural pathways, with preclinical research showing promising effects on memory and learning in animal models. While much of the current evidence comes from laboratory and animal studies, early findings have generated considerable enthusiasm in the longevity research community, and human clinical trials are underway to better understand its effects on aging and overall health.

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What the research says

Common dosages

These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.

Form Dose range Frequency Studied for Source
Capsule 100 mg Daily cognitive function and neuroprotection in older adults Dose used in pilot cognitive studies including work by Maher et al.
Capsule 100–200 mg Daily general antioxidant support and cognitive function Common in early human trials and commercial formulations
Capsule 500 mg Daily inflammation and antioxidant support Used in human supplementation studies examining bioavailability and inflammation markers
Capsule 20 mg/kg Daily for 2 consecutive days senolytic dosing based on body weight for anti-aging research Dose used in Aging Cell 2018 (Kirkland et al.) and related clinical pilot studies
Capsule 1,000–1,500 mg Twice daily for 2 consecutive days senolytic protocol for anti-aging and cellular senescence clearance Based on Mayo Clinic-led clinical trials (NCT02519959, NCT03475056)

Common supplement forms

Fisetin from strawberries/other sources
Medical Disclaimer: Noyemi provides information from published research for educational purposes only. This content is not medical advice and does not replace consultation with a qualified healthcare provider. Always consult your doctor before starting, stopping, or changing any supplement regimen, especially if you take medications or have existing health conditions.