Evening Primrose Oil, derived from the seeds of Oenothera biennis, is valued primarily for its rich concentration of gamma-linolenic acid (GLA), an omega-6 fatty acid involved in inflammatory and hormonal pathways. Research suggests that GLA supplementation may support relief from premenstrual symptoms such as breast tenderness and mood changes, and some studies indicate potential benefits for skin conditions like eczema by helping restore moisture and reduce inflammation. There is also emerging interest in its role in supporting nerve function, particularly in individuals with metabolic health concerns, as well as modest evidence around joint comfort. While findings across studies vary in strength and consistency, Evening Primrose Oil remains one of the more widely researched herbal oils, with a long history of traditional and complementary use for hormonal and inflammatory support.
Compare this supplementResearch suggests that evening primrose oil has not demonstrated meaningful effectiveness for cyclical breast pain (m...
View studies →Research suggests that evening primrose oil does not appear to offer meaningful relief for PMS symptoms beyond placeb...
View studies →Research suggests that evening primrose oil (EPO) may support nerve function, particularly in the context of diabetic...
View studies →Research suggests that evening primrose oil may play a role in hormonal balance indirectly, as evidenced by a large o...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 3,000–4,000 mg | Daily | Breast pain (mastalgia) and breast health | Common in clinical trials for cyclic mastalgia |
| Capsule | 360–480 mg | Daily | Diabetic neuropathy and nerve function | Expressed as GLA dose in clinical trials for peripheral neuropathy |
| Capsule | 3,000–6,000 mg | Daily | Eczema relief and atopic dermatitis | Based on RCTs investigating GLA content for skin conditions |
| Capsule | 500–1,000 mg | Twice daily | PMS relief and hormonal balance | Common in clinical trials for premenstrual syndrome |
| Capsule | 6,000 mg | Daily | Rheumatoid arthritis and joint pain relief | Based on RCTs evaluating anti-inflammatory effects of GLA |
| Oil | 1,000–2,000 mg | Daily | General health and hormonal balance maintenance | Commonly referenced maintenance dose in observational studies |