Epicatechin is a naturally occurring flavanol found abundantly in cocoa, green tea, and certain fruits, and it has drawn considerable research interest for its potential cardiovascular and metabolic benefits. Studies indicate that epicatechin may support healthy blood circulation by promoting nitric oxide production, which helps relax blood vessels and improve blood flow. Research also suggests it may play a role in blood sugar regulation by enhancing insulin sensitivity, and emerging evidence points to possible benefits for muscle strength and growth through pathways involving follistatin and myostatin balance. Most clinical research has utilized cocoa flavanol extracts as the primary delivery form, and while early findings are promising across exercise performance and cardiometabolic health, larger and longer-term trials are still needed to fully understand its effects.
Compare this supplementResearch suggests that epicatechin shows promising effects on exercise performance and muscle physiology in animal st...
View studies →Research suggests that epicatechin and related flavonoids may support blood circulation through several mechanisms, i...
View studies →Research suggests that epicatechin may support muscle health through mechanisms related to mitochondrial biogenesis, ...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 50–150 mg | Daily | Blood circulation | Common range in clinical trials examining endothelial function and nitric oxide production |
| Capsule | 25–50 mg | Twice daily | Blood sugar regulation | Doses studied in trials on insulin sensitivity and glucose metabolism |
| Capsule | 75–150 mg | Daily | Exercise performance | Used in studies on VO2 max, mitochondrial biogenesis, and exercise capacity |
| Capsule | 50–100 mg | Twice daily | Muscle strength and growth | Used in RCTs examining skeletal muscle hypertrophy and strength gains |