Creatine for Exercise Performance

Strong evidence 26 studies

Research suggests that creatine supplementation is one of the more consistently supported ergogenic aids in the sports nutrition literature, with multiple reviews and position statements — including those from the International Society of Sports Nutrition — finding reliable improvements in high-intensity, short-duration exercise performance, maximal strength, power output, and fat-free mass gains, largely through enhanced intracellular creatine stores and improved ATP regeneration. Studies indicate these benefits extend across diverse populations, including adult men and women, adolescents, and older adults, with women and vegetarians potentially seeing amplified effects due to lower baseline creatine levels, and emerging evidence pointing to additional recovery benefits such as reduced muscle damage and faster restoration of force production between exercise bouts. The evidence is more mixed, however, when it comes to endurance-based exercise and situations where increased body mass may be a disadvantage, and the bulk of the strongest supporting evidence comes from reviews and narrative syntheses rather than a uniformly large body of independent randomized controlled trials on every specific use case. Several studies linked here examining related topics — such as cold water immersion, sodium bicarbonate, massage, and nanobubble water — do not directly investigate creatine but collectively illustrate the broader, competitive landscape of recovery and performance research within which creatine's evidence base remains comparatively robust.

Related studies

Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.

Title Type Year Direction Match
International Society of Sports Nutrition position stand: safety and efficacy... Review 2017 Supports 100
Creatine for Exercise and Sports Performance, with Recovery Considerations fo... Review 2021 Mixed 95
Creatine Supplementation in Women's Health: A Lifespan Perspective. Review 2021 Supports 90
Ultra-small Particle Size Nanobubbles Water Drinking Exerts Antifatigue Effec... Other 2024 Neutral 85
International Society of Sports Nutrition position stand: sodium bicarbonate ... Review 2021 Neutral 85
Global skeletal muscle metabolomics reveals mechanisms behind higher response... Other 2025 Neutral 80
Effects of cold water immersion after exercise on fatigue recovery and exerci... Systematic review 2023 Neutral 80
Bat power-metabolic profiling of the Egyptian fruit bat <i>Rousettus aegypti... Other 2025 Neutral 75
Nutritional Strategies to Improve Post-exercise Recovery and Subsequent Exerc... Review 2025 Supports 75
Altered systemic bioenergetic reserve in chronic kidney disease predisposes h... Other 2024 Neutral 70
Creatine Supplementation Beyond Athletics: Benefits of Different Types of Cre... Review 2024 Supports 70
Exercise on cytokine responses in males and females: Effect of leucine, HMB a... Other 2023 Neutral 65
The Effects of Massage Therapy on Sport and Exercise Performance: A Systemati... Review 2023 Neutral 65
Enhancement of Prednisolone efficacy and safety in Duchenne muscular dystroph... Other 2025 Neutral 60
Creatine Supplementation in Children and Adolescents. Review 2021 Supports 60
Shared genetic architecture links energy metabolism, behavior and starvation ... Other 2024 Neutral 55
Effects of Creatine Supplementation on Athletic Performance in Soccer Players... Meta-analysis 2019 Mixed 55
Relationships between acute race-induced changes in creatine kinase activity ... Other 2021 Neutral 50
Timing of Creatine Supplementation around Exercise: A Real Concern? Review 2021 Supports 50
A Ray of Light Against Age Related Neurodegeneration Other 2023 Neutral 45
Creatine and Caffeine: Considerations for Concurrent Supplementation. Review 2015 Mixed 45
Part II. Common questions and misconceptions about creatine supplementation: ... Review 2025 Supports 40
Voluntary wheel running mitigates disease in an Orai1 gain-of-function mouse ... Other 2023 Neutral 40
The Effect of Creatine Nitrate and Caffeine Individually or Combined on Exerc... RCT 2024 35
Metabolic snapshot of plasma samples reveals new pathways implicated in SARS-... Other 2021 Neutral 35
Creatine in women's health: bridging the gap from menstruation through pregna... Review 2025 Supports 30

← Back to Creatine

Medical Disclaimer: Noyemi provides information from published research for educational purposes only. This content is not medical advice and does not replace consultation with a qualified healthcare provider. Always consult your doctor before starting, stopping, or changing any supplement regimen, especially if you take medications or have existing health conditions.