Research suggests that Cramp Bark (Viburnum opulus) contains bioactive compounds, notably scopoletin and viopudial, that have been identified in laboratory studies as smooth muscle antispasmodics, providing a plausible pharmacological basis for its traditional use in relieving menstrual cramps. Studies indicate that the plant also demonstrates anti-inflammatory properties in laboratory and phytochemical analyses, which may further support its relevance to dysmenorrhea. The available evidence base consists primarily of phytochemical studies, ethnobotanical documentation, and traditional use records from 1967 through 2024, with no randomized controlled trials or clinical studies identified in this set, which is a notable limitation when evaluating efficacy in humans. The consistent ethnopharmacological record across cultures and time periods lends contextual support to the claim, but readers should be aware that mechanistic and traditional evidence does not substitute for clinical proof of effectiveness.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| Scopoletin, an Antispasmodic Component of Viburnum opulus and prunifolium. | Other | 1967 | Supports | 80 |
| Viburnum opulus L.: A remedy for the treatment of endometriosis demonstrated ... | Other | 2016 | Supports | 78 |
| Viopudial, a hypotensive and smooth muscle antispasmodic from Viburnum opulus. | Other | 1972 | Supports | 72 |
| Gilaburu (Viburnum opulus L.) fruit extract has potential therapeutic and pro... | Other | 2024 | Supports | 57 |