Cat's Claw (Uncaria tomentosa) is a woody vine native to the Amazon rainforest, where it has a long history of traditional use for a variety of health concerns. Research suggests that compounds found in its bark, including oxindole alkaloids and polyphenols, may support immune function and contribute to anti-inflammatory and antioxidant activity. Studies indicate potential benefits for joint comfort, with some clinical trials showing modest improvements in pain and stiffness associated with osteoarthritis and rheumatoid arthritis. Preliminary research has also explored its role in supporting digestive health and protecting cells from oxidative stress. While findings are promising, much of the evidence remains early-stage, and the quality of extracts can vary considerably between products, making it worth exploring the available literature thoughtfully.
Compare this supplementResearch suggests that cat's claw (Uncaria tomentosa and related species) possesses meaningful anti-inflammatory prop...
View studies →Research suggests that cat's claw extracts may support immune function through several mechanisms, including increasi...
View studies →Research suggests mixed and inconclusive findings for cat's claw in supporting joint health, based on the available p...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 20–60 mg | Three times daily | Digestive health and general immune support | Traditional and clinical use range for bark extract standardized to oxindole alkaloids |
| Capsule | 250–300 mg | Twice daily | Joint health and anti-inflammatory support | Used in RCTs for osteoarthritis and rheumatoid arthritis (Mur et al., 2002; Piscoya et al., 2001) |
| Extract | 300–350 mg | Daily | Anti-inflammatory and joint health | Freeze-dried aqueous extract used in osteoarthritis RCTs (Piscoya et al., 2001) |
| Extract | 100 mg | Daily | DNA repair and antioxidant support | C-Med-100 aqueous extract studied for DNA repair enhancement (Sheng et al., 2001) |
| Extract | 60 mg | Daily | Immune function and antioxidant support | Standardized extract (C-Med-100) studied in clinical trials for immune modulation (Sheng et al., 2000) |