Cat's Claw, derived from the inner bark of Uncaria tomentosa, is a woody vine native to the Amazon rainforest with a long history of traditional use among indigenous communities. Research suggests that its bioactive compounds, particularly oxindole alkaloids and polyphenols, may support healthy immune function and contribute to anti-inflammatory activity, making it a subject of growing scientific interest for joint comfort and mobility. Studies indicate that Cat's Claw extracts may also play a role in supporting cellular health by influencing antioxidant pathways and modulating immune responses, though more large-scale clinical trials are needed to fully understand its mechanisms. Available primarily as capsules, teas, and liquid extracts, it remains one of the more widely studied botanical supplements from the South American tradition.
Compare this supplementResearch suggests that Cat's Claw, specifically compounds derived from Uncaria species hook-bearing stems, displays a...
View studies →Research on Cat's Claw specifically for cell health is not represented in the available evidence base for this topic....
View studies →Research on cat's claw specifically for immune function is not represented in the available evidence base for this en...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 300–500 mg | Daily | General immune function and cell health | Common standardized dosing in human supplementation studies |
| Capsule | 250–350 mg | Three times daily | Osteoarthritis and joint pain relief | Based on RCTs studying U. tomentosa for knee osteoarthritis |
| Extract | 60–300 mg | Daily | Anti-inflammatory and immune function support | Common in clinical trials using standardized U. tomentosa extract |
| Extract | 450 mg | Three times daily | DNA repair and cell health support | Used in trials examining oxidative stress and DNA damage markers |
| Extract | 20–60 mg | Twice daily | Rheumatoid arthritis and joint inflammation | Used in clinical trials with freeze-dried aqueous extract (AC-11 or similar) |