Research suggests that calcium supplementation is among the better-supported natural options for reducing premenstrual syndrome symptoms, with a 2009 systematic review of randomized controlled trials identifying it as having the strongest evidence among natural products evaluated for PMS relief, and a 2002 clinical review recommending calcium carbonate as a first-line option for mild-to-moderate PMS. Several additional reviews from 2003 and 2023 similarly identify calcium as one of a handful of micronutrients showing meaningful promise for PMS management, alongside magnesium, vitamin D, and B vitamins. One 2025 randomized controlled trial found benefit from a multi-ingredient supplement containing calcium citrate among other components, though its findings cannot be attributed to calcium alone. Taken together, the available evidence is generally supportive but carries notable limitations — most reviews acknowledge that study designs vary considerably, the overall body of research remains methodologically inconsistent, and no review concludes the evidence is strong enough to formally recommend calcium as a proven treatment.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| Impact of nutritional diet therapy on premenstrual syndrome. | Review | 2023 | Supports | 72 |
| Natural relief for premenstrual syndrome (PMS): a double-blind clinical trial... | Other | 2025 | Mixed | 67 |
| Herbs, vitamins and minerals in the treatment of premenstrual syndrome: a sys... | Systematic review | 2009 | Supports | 62 |
| A review of treatment of premenstrual syndrome and premenstrual dysphoric dis... | Review | 2003 | Supports | 57 |
| Is it premenstrual syndrome? Keys to focused diagnosis, therapies for multipl... | Review | 2000 | Neutral | 52 |
| Premenstrual syndrome. Evidence-based treatment in family practice. | Other | 2002 | Supports | 47 |
| Phalangeal microgeodic syndrome: case report of a young woman treated with pe... | Other | 2024 | Neutral | 42 |