Research suggests that boron plays a role in hormone metabolism, including testosterone regulation, though the evidence for its use as a testosterone-boosting supplement is notably mixed and context-dependent. Two randomized controlled trials conducted in young male bodybuilders found that boron supplementation produced no statistically significant advantage over placebo for testosterone levels, lean body mass, or strength, with improvements in both groups attributed to resistance training itself; a 2015 narrative review, by contrast, reported broader evidence that adequate boron intake supports hormone metabolism and other biological functions, while a 2008 systematic review concluded that findings on hormone regulation specifically remain conflicting and that rigorous human trials are still lacking. Studies also indicate that at very high doses boron compounds can cause testicular damage and hormonal disruption in animals, though toxicological reviews estimate that normal human exposure levels fall well within established safety margins, and an occupational study found no reproductive harm in workers with substantially elevated daily intake. Overall, the body of evidence — drawn primarily from small trials, narrative reviews, and observational data rather than large high-quality RCTs — does not currently support boron supplementation as a reliable means of elevating testosterone, and researchers consistently call for more rigorous human studies before stronger conclusions can be drawn.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| Nothing Boring About Boron. | Review | 2015 | Supports | 72 |
| Boron. | Review | 2008 | Mixed | 67 |
| The role of boron in nutrition and metabolism. | Review | 1993 | Mixed | 62 |
| Plasma boron and the effects of boron supplementation in males. | RCT | 1994 | — | 57 |
| The effect of boron supplementation on lean body mass, plasma testosterone le... | RCT | 1993 | — | 52 |
| Reproductive toxicity parameters and biological monitoring in occupationally ... | Other | 2011 | Neutral | 47 |
| Dietary boron intake and prostate cancer risk. | Other | 2004 | Neutral | 42 |
| Reproductive toxicity of metals in men. | Review | 2012 | Neutral | 37 |
| The influence of a low-boron diet and boron supplementation on bone, major mi... | Other | 1993 | — | 32 |
| Testosterone and dihydrotestosterone inhibit gallbladder motility through mul... | Other | 2008 | Neutral | 27 |
| General, reproductive, developmental, and endocrine toxicity of boronated com... | Review | 1998 | Mixed | 22 |
| Synthesis and spectral properties of estrogen- and androgen-BODIPY conjugates. | Other | 2017 | Neutral | 17 |