Vitamin B7 (Biotin) for Blood Sugar Regulation

Research suggests that biotin supplementation may have some role in blood sugar and metabolic regulation, though the evidence remains limited and inconsistent across study types. A 2022 systematic review and meta-analysis of five randomized controlled trials found that biotin was associated with reductions in total cholesterol but did not produce statistically significant improvements in fasting blood glucose or insulin levels, while a 2006 randomized controlled trial similarly found no meaningful effect on blood glucose despite observing reductions in triglycerides. Animal studies, including a rat model from 2015 and a mouse study from 2010, report more favorable findings, showing reductions in post-meal blood sugar and triglycerides alongside changes in gene expression related to glucose and fat metabolism, though these results cannot be directly applied to humans. Overall, the body of evidence on biotin for blood sugar regulation is modest in size, methodologically mixed, and largely preliminary, with researchers across multiple studies calling for larger and longer trials before any firm conclusions can be drawn.