Serotonergic

Danger

Supplements that increase serotonin levels or activity in the brain.

Stacking risk

Combining multiple serotonergic supplements can cause serotonin syndrome, a potentially life-threatening condition with symptoms including agitation, confusion, rapid heart rate, high blood pressure, and seizures. EXTREMELY dangerous when combined with SSRIs, SNRIs, MAOIs, or tramadol.

Supplements with this effect

5-HTP (strong) St. John's Wort (strong) L-Tryptophan (moderate) SAMe (S-Adenosyl Methionine) (moderate) Saffron (mild)

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Medical Disclaimer: Noyemi provides information from published research for educational purposes only. This content is not medical advice and does not replace consultation with a qualified healthcare provider. Always consult your doctor before starting, stopping, or changing any supplement regimen, especially if you take medications or have existing health conditions.